Somatostatin Analogs in Diagnostics and Therapy
|
Edited By:Marek PawlikowskiMedical University of Lodz Lodz, Poland ISBN: 978-1-58706-223-0 Published: 2007-04-03 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Somatostatin is a peptide isolated originally from the hypothalamus and considered as an inhibitor of growth hormone secretion. However, further studies have shown that the peptide was ubiquitously distributed and exerts a large spectrum of physiological effects, mostly of an inhibitory nature. The very short half-life of the native peptide limits its therapeutic application. To overcome this limitation the long-lasting modified molecules (analogs) of somatostatin were synthesized. The present book provides comprehensive data on the application of somatostatin analogs in diagnostics and treatment of diseases, mostly endocrine disorders and cancers.
Chapters available from this book
Somatostatin Analogs—New Perspectives
Gabriela Melen-Mucha and Marek Pawlikowski
Acromegaly and so-called neuroendocrine tumors (carcinoids, pancreatic endocrine tumors) are at present the only routine indications for somatostatin (SST) analogs therapy. However, the progress in the studies on somatostatin receptors (sst) and the development of the numerous new SST analog...
The Treatment of Acromegaly with Somatostatin Analogs
Nuria Sucunza, Mª José Barahona and Susan M. Webb
Although transsphenoidal surgery of pituitary micro or macroadenomas is the treatment of choice in most acromegalic patients, somatostatin analogs are the first choice for medical treatment, either primary or secondary. Nowadays, two forms of octreotide, s.c. short- and i.m. long-acting, and t...
Somatostatin Receptors: Distribution in Normal Tissues and Transduction Mechanisms
Gabriela Melen-Mucha and Slawomir Mucha
receptors belonging to the family of G protein coupled receptors. So far five SST receptor subtypes (sst1-5) have been cloned and characterized. The genes for these receptor subtypes are localized on different chromosomes and are intronless, with one exception concerning sst2, which exists in tw...
Somatostatin Receptors in Human Tumors: In Vitro Studies
Marek Pawlikowski
Neoplastic cells express and often even over-express the somatostatin receptors. It is important because the presence of sst receptors predicts—to some extent—the possibility of treatment with SST analogs. The presence of sst receptors may be examined in vivo, by means of the receptor scinti...
Physiology of Somatostatin
Marek Pawlikowski
Somatostatin (SST) was originally discovered as a hypothalamic peptide which inhibits growth hormone (GH) secretion from the pituitary gland. It appears in two molecular forms, composed from 14 or 28 amino-acid residues. Moreover, another family of peptides, called cortistatins (CST), was desc...
The Treatment of Neuroendocrine Tumors (NET) with Somatostatin Analogs
Beata Kos-Kudla
There is increasing interest in somatostatin (SST) analogs in the diagnosis and therapy of neuroendocrine tumors (NET), which constitute a heterogeneous group of neoplasms often associated with typical symptoms due to excessive production of hormones and bioactive substances. SST analogs have ...
Somatostatin Analogs: Lessons in Functional Complexity and Receptor Interactions
Michael D. Culler
Somatostatin (SST) was originally isolated from the hypothalamus as the key suppressor GH secretion, but is now known to be widely distributed throughout the body and to be involved in numerous physiological functions. While the varied activity of SST creates opportunities for its use as a the...
Radiolabeled Somatostatin Analogs in the Diagnosis and Therapy of Neuroendocrine Tumors
Leszek Królicki, Jolanta Kunikowska and Marianna I. Bak
The proof of the principle, that many tumors are characterized by a high expression of somatostatin receptors, has provided the background for the use of somatostatin analogs in the diagnostic process and in the therapy of these tumors. At present, somatostatin receptor scintigraphy can be adequatel...
