The Pombe Cdc15 Homology Proteins
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Edited By:Pontus AspenströmLudwig Institute for Cancer Research Biomedical Center Uppsala University Uppsala, Sweden ISBN: TBA Published: 2009-03-01 |
Chapters available from this book
The PACSIN Proteins and their Role in Membrane Trafficking
Markus Plomann, Matthias Mörgelin and Sylvia Schael
PACSIN 1/syndapin 1 was originally identified by its drastic expression decrease during CNS repair processes and by virtue of its binding to the GTPase dynamin. The three family members play important roles as accessory proteins in clathrin‑mediated endocytosis. They differ in tissue distribut...
F‑BAR Domain Proteins in Schizosaccharomyces pombe
Rachel H Roberts-Galbraith and Kathleen L. Gould
S chizosaccharomyces pombe is a simple model organism ideal for study of conserved proteins of interest. The genome of S. pombe encodes seven proteins containing F‑BAR domains, including four scaffolding proteins of the pombe cdc15 homology (PCH) family and three Rho GTPase activating pr...
The CIP4 Family of F‑BAR Domain‑Containing Proteins
Marcia Toguchi and Pontus Aspenström
The F‑BAR family of proteins has emerged as important coordinators of signaling pathways that regulate actomyosin assembly and membrane dynamics. This review article will focus on the Cdc42‑interacting protein 4 (CIP4) family of proteins. Recently, they have been found to bind phospholip...
The NOSTRIN Subfamily of PCH/F‑BAR Proteins
Ann Siehoff-Icking, Masood Siddique and Werner Müller-Esterl
NOSTRIN is a prototypic PCH/F‑BAR protein with an N‑terminal F‑BAR domain mediating membrane association and a C‑terminal SH3 domain representing a docking platform for various proteins. Human NOSTRIN has recently been shown to function as an adaptor protein in caveolar traff...
FES and FER: The F‑BAR Domain‑Containing Protein‑Tyrosine Kinases
Waheed Sangrar, Andrew W. Craig and Peter A. Greer
FES and FER are the only two members of a distinct subgroup of the protein‑tyrosine kinase (PTK) family. What distinguishes them from other PTKs and indeed all other kinases, are their unique amino‑terminal domains, which contain sequences homologous to the recently solved F‑BAR do...
PSTPIP1 and PSTPIP2/MAYP
Violeta Chitu and E. Richard Stanley
PSTPIP1 and PSTPIP2 are expressed predominantly in the hematopoietic system where their C‑terminal tyrosine phosphorylation is regulated by PEST family phosphatases. Both proteins deform membranes via their conserved F‑BAR domains and regulate actin organization, but their actin regulato...
Boomerangs, Bananas and Blimps: Structure and Function of F‑BAR Domains in the Context of the BAR Domain Superfamily
Adam Frost, Vinzenz M. Unger and Pietro De Camilli
Proteins that belong to the BAR (Bin, Amphiphysin, RVS) domain superfamily are alpha‑helical bilayer‑binding modules that have evolved to induce or stabilize membrane curvature during cellular events like endocytosis, cell division and organelle biogenesis. Within the superfamily, a subs...
The Budding Yeast PCH/F‑BAR Proteins
Alan L. Munn and Barbara Winsor
The budding yeast Saccharomyces cerevisiae genome encodes two classical Pombe Cdc15 Homology (PCH) proteins: Hof1p (or Cyk2p) and Bzz1p (or Lsb7p). Like mammalian PCH proteins, both have an N‑terminal F‑BAR domain and C‑terminal Src Homology 3 (SH3) domain(s). The yeast genome also...
Gas 7
Wenlynn B. Su, Jhong-Jhe You, Bo-Tsang Huang, Vishwanathan Sivakumar, Shauh-Der Yeh and Sue Lin-Chao
Gas7 (growth‑arrest specific gene 7) has recently been classified to be a member of the Pombe Cdc 15 homology (PCH) family and belongs to the proline, serine, threonine‑rich phosphatase interacting protein (PSTPIP) subfamily.1,2 Most PCH proteins share a similar domain architecture, whic...
