Development and Engineering of Dopamine Neurons
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Edited By:R. Jeroen PasterkampRudolf Magnus Institute of Neuroscience University Medical Center Utrecht Utrecht, The Netherlands Marten P. Smidt Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht Utrecht, The Netherlands J. Peter H. Burbach Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht Utrecht, The Netherlands ISBN: TBA Published: 2008-10-01 |
Chapters available from this book
Neurotrophic Support of Midbrain Dopaminergic Neurons
Oliver von Bohlen
In this chapter we review work on neurotrophic factors for midbrain dopaminergic neurons mainly from the past decade, with a focus on neurotrophins and fibroblast growth factors. We summarize data obtained from animal models of Parkinson’s disease, review analyses of neurotrophin, neurotrophin recep...
Dopamine Systems in the Forebrain
John W. Cave and Harriet Baker
The brain contains a number of distinct regions that share expression of dopamine (DA) and its requisite biosynthetic machinery, but otherwise encompass a diverse array of features and functions. Across the vertebrate family, the olfactory bulb (OB) contains the major DA system in the forebrain. OB ...
TGF‑β in Dopamine Neuron Development, Maintenance and Neuroprotection
E. Roussa, O. Krieglsteinvon Bohlen und Halbach and Kerstin Krieglstein
Transforming growth factor betas (TGF‑βs) are multifunctional cytokines with widespread distribution. In the nervous system the biological effects of TGF‑β cover regulation of proliferation, migration, differentiation, survival and death. Specifically, the effects of TGF‑...
Development of the Dopamine Systems in Zebrafish
Jörn Schweitzer and Wolfgang Driever
Dopaminergic neurons develop in several distinct regions of the vertebrate brain and project locally or send long axonal projections to distant parts of the CNS to modulate the activity of a variety of circuits, controlling aspects of physiology, behavior and movement. The molecular control of dopam...
Molecular and Cellular Determinants for Generating ES‑Cell Derived Dopamine Neurons for Cell Therapy
Jan Pruszak and Ole Isacson
Embryonic stem (ES) cells can generate midbrain dopaminergic (DA) neuronal phenotypes in vitro and have been successfully applied to restore function in animal models of Parkinson’s disease (PD). How can we best integrate our growing insight into the regulatory cascade of transcription factors guidi...
The Role of Otx genes in Progenitor Domains of Ventral Midbrain
Antonio Simeone, Eduardo Puelles, Dario Acampora, Daniela Omodei, Pietro Mancuso and Luca Giovanni Di Giovannantonio
The mesencephalic dopaminergic (mesDA) neurons play a relevant role in the control of movement, behaviour and cognition. Indeed loss and/or abnormal development of mesDA neurons is responsible for Parkinson’s disease as well as for addictive and psychiatric disorders. A wealth of information has bee...
Axon Guidance in the Dopamine System
Asheeta A. Prasad and R. Jeroen Pasterkamp
Meso‑diencephalic dopamine neurons (mdDA) neurons are located in the retrorubral field (RRF), substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) and give rise to prominent ascending axon projections. These so‑called mesotelencephalic projections are organized into thre...
Transcriptional Regulation of their Survival: The Engrailed Homeobox Genes
Horst H. Simon and Kambiz N. Alavian
The mammalian Engrailed genes were originally cloned by their sequence homology to the Drosophila engrailed. Orthologous genes of these homeobox transcription factors are found throughout the animal kingdom including all investigated vertebrate species. They take part in regionalization of the early...
Terminal Differentiation of Mesodiencephalic Dopaminergic Neurons: the role of Nurr1 and Pitx3
Marten P. Smidt and J. Peter H. Burbach
The orphan nuclear hormone receptor Nurr1 and the homeobox Pitx3 were the first two transcription factors that were implicated in the development of mesodiencephalic dopaminergic (mdDA) neurons.1,2 These factors have their own expression profile in the brain: Nurr1 is expressed in many forebrain reg...
Foxa1 and Foxa2 Transcription Factors Regulate Differentiation of Midbrain Dopaminergic Neurons
Siew-Lan Ang
Midbrain dopaminergic neurons (mDA), comprising the substantia nigra pars compacta (A8), the ventral tegmental area (A9) and the retrorubal field (A10) subgroups, are generated from floor plate progenitors, rostral to the isthmic boundary. Floor plate progenitors are specified to become mDA progenit...
