Leptin and Leptin Antagonists
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Edited By:Arieh GertlerInstitute of Biochemistry The Hebrew University of Jerusalem ISBN: TBA Published: 2008-09-01 |
Chapters available from this book
The Use of Leptin for the Treatment of Lipodystrophy
Angeline Y. Chong, Elaine K. Cochran and Phillip Gorden
Leptin was the first of the adipocyte‑secreted hormones, later termed adipokines, to be identified. It is used clinically to treat hypoleptinemic states, such as congenital leptin deficiency and lipodystrophy. In this chapter, we discuss the effects of leptin administration in patients with li...
Study of Leptin: Leptin Receptor Interaction by FRET and BRET
Julie Dam, Cyril Couturier, Patty Chen and Ralf Jockers
Understanding the molecular mechanism of the leptin:leptin receptor (OB‑R) interaction and the OB‑R activation process is crucial for the development of drugs that target OB‑Rs. Recently developed resonance energy transfer (RET)‑based assays participated significantly in the ...
Leptin as a Novel Marker in Breast and Colorectal Cancer
Eva Surmacz and Mariusz Koda
Obesity, defined as Body Mass Index (BMI) ≥30, constitutes a known risk factor for the development of different neoplasms, including such common diseases as postmenopausal breast cancer and colorectal cancer.1 According to the National Cancer Institute significant excess of body weight increas...
Leptin Signal Transduction—A 2008 Update
Walter Becker
Leptin is an adipocyte‑secreted hormone that informs the brain about the status of the body’s energy stores. Leptin controls energy homeostasis through effects on satiety and energy expenditure but also regulates other processes, including reproduction, glycemic control, immune function and wo...
Is Leptin a Pro‑ or Anti‑Apoptotic Agent?
Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati and Clifton A. Baile
Apoptosis, the regulated destruction of a cell, is characterized by biological and morphological changes and involves a large web of integrating pathways and factors. Apoptosis is necessary to eliminate excess cells and cells that hinder development and hence the importance of apoptotic pathways and...
Involvement of Leptin in Arterial Hypertension
Jerzy Beltowski
Leptin is secreted by white adipose tissue and its concentration in plasma is higher in obese than in lean subjects. Recent studies suggest that leptin is involved in cardiovascular complications of obesity including arterial hypertension. Acutely administered leptin has no effect on blood pressure,...
Insights in the Activated LR Complex and the Rational Design of Antagonists
Frank Peelman, Lennart Zabeau and Jan Tavernier
The hormone leptin plays an important role in the control of body weight. Leptin is mainly produced and secreted by adipocytes as a 16 kDa nonglycosylated polypeptide and plasma leptin levels positively correlate with body fat energy stores. To a lesser extent, leptin is also expressed in other tiss...
