Maspin
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Edited By:Mary J.C. HendrixUniversity of Iowa ISBN: 978-1-58706-097-7 Published: 2002-08-01 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Maspin, a Potential Prognostic Marker for Human Cancers
Mickey C-T. Hu, Weiya Xia and Mien-Chie Hung
Maspin (mammary serine protease inhibitor) is a 42 kDa protein that shares significant sequence homology with several members of the serpin (serine protease inhibitor) family, including plasminogen activation inhibitors 1 and 2 (PAI-1 and PAI...
The Role of Maspin in Human Placental Development
Anuja Dokras, Lynn M.G. Gardner, Dawn A. Kirschmann, Elisabeth A. Seftor and Mary J.C. Hendrix
The human placenta is hemochorial and displays highly regulated invasive activity and exponential growth potential. The stem cell cytotrophoblasts undergo differentiation along two pathways: they fuse to form multinucleate syncytiotrophoblasts or they detach from the ba...
The Role of Maspin in Tumor Progression and Normal Development
Ming Zhang
Serine protease inhibitors (serpins) are comprised of a large family of molecules that play a variety of physiological roles in vivo.1-3 Not all molecules that inhibit serine proteases are termed serpins. But all serpins have a very special protein str...
Maspin Suppresses Breast Cancer Cell Invasiveness by Modulating Integrin Expression and Function
Richard E.B. Seftor, Valerie A. Odero, Elisabeth A. Seftor and Mary J.C. Hendrix
Although the novel tumor suppressor gene maspin (mammary serine protease inhibitor) was originally isolated from normal mammary epithelium by subtractive hybridization and differential display almost seven years ago,1-2 it is still unclear how it funct...
Genetic and Epigenetic Regulation of Maspin Gene Expression in Normal and Tumor Tissue
Frederick E. Domann and Bernard W. Futscher
Maspin, a tumor suppressor gene, encodes a protein that has been shown to restrict breast cancer cell motility, invasion, and metastasis. Expression of the maspin gene is commonly silenced during breast cancer progression, and this loss of expression has been shown to o...
Maspin and Pericellular Plasminogen Activation in Cell-Matrix Interaction
Shijie Sheng, Hector Biliran Jr. and Richard McGowen
Maspin may offer a unique opportunity to block tumor invasion and metastasis. Maspin expression correlates with normality, and pre-malignant and/or less invasive lesions in breast, prostate and oral squamous cells.15 Therefore, maspin may be a useful molecula...
Maspin and Myoepithelial Cells
Sanford H. Barsky, Paul Kedeshian and Mary L. Alpaugh
Host cellular paracrine regulation of tumor progression is an important determinant of tumor growth, invasion and metastasis but one cell which has largely been ignored in this regulation is the myoepithelial cell. In any organ where there is significant branching morph...
Maspin: Functional Insights from a Structural Perspective
Philip A. Pemberton
Since the seminal paper by Zou et al1 identifying the existence of the novel tumor suppressor maspin (mammary serpin), research efforts have largely focused on the mechanism of action of the protein and its utility as a prognostic indicator for other types of...
Maspin in the Sager Laboratory
Ming Zhang, Shijie Sheng and Arthur B. Pardee
Discovery of a disease-related gene marks only the beginning to a series of difficult investigations. In order to establish the functional role of the newly discovered gene, one has to obtain insights into its biological activities, genetic and epigenetic regulations...
Ruth Sager, Geneticist
Arthur B. Pardee
Ruth Sager named her favorite gene Maspin, mammary serpin protease inhibitor. Expression of this gene is lost in advanced breast cancers and inhibits tumor invasion and metastasis. This book highlights advances made in studies that developed from her laboratory's res...
