Fas Signaling
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Edited By:Harald WajantUniversity of Wuerzburg Wuerzburg, Germany ISBN: 978-0-387-32172-1 Published: 2006-04-03 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well-recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for anyone with an interest in the biology of this exciting molecule.
Chapters available from this book
The FasL-Fas System in Disease and Therapy
Harald Wajant and Frank Henkler
The physiological roles of the FasL-Fas system include apoptosis-related processes like tumor surveillance, elimination of virus infected cells or deletion of autoreactive T- and B-cells. In recent years there is also emerging evidence for nonapoptotic functions of these molecules in liver regene...
Fas-More Than an Apoptosis Inducer
Harald Wajant
Fas (Apo-1 or CD95) and its corresponding ligand FasL (CD95L) are representative members of the TNF receptor and TNF ligand family that have been implicated in a variety of apoptotic processes, involved in T-cell induced cytotoxicity, activation-induced cell death, immune privilege, tumor surveil...
FasL and Fas: Typical Members of the TNF Ligand and Receptor Family
Anja Krippner-Heidenreich and Peter Scheurich
The membrane receptor Fas is one of the central members of the TNF receptor superfamily, representing the prototype of an apoptosis inducer. Its cognate ligand, FasL, is expressed as a type II transmembrane protein, but also exists as a soluble molecule. Typical for all members of the receptor su...
Fas Induced Necrosis
Tom Vanden Berghe, Nele Festjens, Michael Kalai, Xavier Saelens and Peter Vandenabeele
Fas/CD95 is an important regulator of cell death in development and homeostasis of the immune system. Apoptosis is the most frequently observed type of cell death induced by Fas. It is characterized by cell shrinkage and nuclear fragmentation, while organelles and the plasma membrane retain their...
Retrograde Fas Ligand Signaling
A. Linkermann, J. Qian and O. Janssen
As highlighted in the previous chapters, the interaction of Fas with Fas Ligand (FasL) affects many different aspects related to activation and apoptosis of Fas-expressing immune and tumor cells. Over the past five years we have learned, however, that FasL also acts as a costimulatory or accessor...
Fas-Activation, Development and Homeostasis of T Cells
Georg Hacker
Fas (APO-1/CD95) is found on various cells of the immune system where its expression depends on differentiation and activation status of the cells. Analysis of the function of Fas on T lymphocytes has been the objective of many studies. Like in most cells carrying Fas, ligation by antibodies or F...
FasL and Fas in Liver Homeostasis and Hepatic Injuries
Maria Eugenia Guicciardi and Gregory J. Gores
Fas is a death receptor expressed by every cell type in the liver. Engagement of Fas with its cognate ligand, Fas ligand (FasL), initiates a signaling cascade resulting in cell death by apoptosis. Fas plays a central role in maintaining liver homeostasis by contributing to the elimination of sene...
Role of Ceramide in CD95 Signaling
Volker Teichgr?ber, Gabriele Hessler and Erich Gulbins
Recent studies indicate that the reorganization of receptor molecules in distinct domains of the cell membrane constitutes an important and general mechanism that is required for the initiation of signaling via various receptor molecules. Studies on the CD95 receptor might serve as a paradigm for...
FasL-Independent Activation of Fas
Faustino Mollinedo and Consuelo Gajate
Fas death receptor (also named CD95 or APO-1) is physiologically activated through binding to its cognate ligand, FasL. Fas/FasL interaction induces oligomerization and aggregation of Fas receptor, leading eventually to apoptosis after protein-protein interactions with adaptor and effector protei...
Tools for Activation and Neutralization of Fas Signaling
Pascal Schneider
Apoptosis mediated by the Fas / FasL pair of receptor and ligand is involved in physiological or pathological processes in which cell death is either required to eliminate potentially harmful infected, transformed or autoreactive cells, or is detrimental when healthy cells like hepatocytes are ma...
Regulation of Fas Signaling by FLIP Proteins
Margot Thome
Fas is a member of the tumor necrosis factor receptor family that can induce apoptosis by the recruitment and activation of caspase-8 (formerly called FLICE, MACH or MCH-5). Recently, caspase-8/FLICE inhibitory proteins (FLIPs) have been identified as proteins that counteract the caspase-8-depend...
