Hyperthermia in Cancer Treatment:
A Primer
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Edited By:Gian Franco BaronzioPolicinico di Monza Erich Dieter Hager Biomed Klinic Germany ISBN: 978-0-387-33440-0 Published: 2006-09-15 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.
Chapters available from this book
Locoregional Hyperthermia
E. Dieter Hager
Locoregional hyperthermia can be differentiated into external, interstitial and endocavitary hyperthermia. Different heat delivery systems are available: antennae array, capacitive coupled, and inductive devices. Depending on localization and size of the tumour different methods and techniques c...
Tumor Ablation Using Radiofrequency Energy: Technical Methods and Application on Liver Tumors
Johannes-Marcus Hänsler, Luigi Solbiati, E. Dieter Hager, Tiziana Ierace, Luca Cova and Gianfranco Baronzio
Radiofrequency ablation is used for the treatment of a variety of neoplasms including: osteoid osteoma, hepatocellular carcinoma, renal cell carcinoma, bronchopulmonary carcinoma, parathyroid adenoma;1 hepatic and retroperitoneal metastases from a variety of primary tumors. The size of the coagu...
Intracavitary Hyperthermic Perfusion
E. Dieter Hager
Direct intra-peritoneal (IP) installation of anticancer agents for the treatment of patients with peritoneal carcinomatosis or sarcomatosis has pharmacological advantages compared to intravenous systemic therapy in terms of local drug concentrations (Table 1). The ratio of antineoplastic agent in th...
Cytoreduction, Peritonectomy and Hyperthermic Antiblastic Peritoneal Perfusion for the Treatment of Peritoneal Carcinomatosis
Michele De Simone* and Marco Vaira
Peritoneal carcinomatosis may present as synchronous disease or like evolution of gastrointestinal or female genital tumors (including pseudomyxoma peritonei, a variable malignancy myxoid tumor, arising from the appendix). It is also the common way of presentation of primitive peritoneal tumors ...
Fever, Pyrogens and Cancer
Ralf Kleef* and E. Dieter Hager
The observation, that cancer patients who experienced a feverish period after surgery survived significantly longer than patients without fever and the fact, that spontaneous tumor remission was observed mostly after a fever period, was the rationale for the artificial induction of fever (“fever...
Thermotherapy and Nanomedicine: Between Vision and Reality
Andreas Jordan
Although nanoparticles have been already applied on patients in clinical trials, generally nanotechnology in medicine is regarded rather a vision than a realistic option. Progress in this field arises particularly from the combination of molecular biology and nano(bio)technology. From the viewpo...
Whole Body Hyperthermia at 43.5-44?C: Dreams or Reality?
Alexey V. Suvernev, Georgy V. Ivanov, Anatoly V. Efremov and Roman Tchervov
A high level of body temperature (43?C) is needed for effective use of whole body hyperthermia. Such high level hyperthermia can only be safely used, taking into account a theory of developing post-aggressive hyperproteolysis.1,2 Besides the control of proteolysis it is also necessary to apply a t...
Thermo-Chemo- Radiotherapy Association: Biological Rationale, Preliminary Observations on Its Use on Malignant Brain Tumors
GianFranco Baronzio,* Vincenzo Cerreta, Attilio Baronzio, Isabel Freitas, Marco Mapelli and Alberto Gramaglia
This review focuses on the biological rationale and the advantages for combining hyperthermia radiotherapy and chemotherapy. Other clinical aspects such as sequence of administration, effects on drug uptake and methods used to improve the efficacy of HT are also discussed. The actual applications...
Future Perspectives of Interstitial and Perfusional Hyperthermia
Gian Franco Baronzio,* Michele De Simone, Gianmaria Fiorentini, Salvatore D’Angelo, Giovanni Visconti and E. Dieter Hager
Recent developments in thermal ablation and perfusion hyperthermia have expanded the treatment options of patients with certain cancer. Initially thermal ablation was applied to liver tumor, later its application has been extending for treating focal malignancies confined in other organs such as:...
Physical Background and Technical Realizations of Hyperthermia
Andras Szasz,* Oliver Szasz and Nora Szasz
Hyperthermia is a medical heat-treatment, widely used in various medical fields and has a well-recognized effect in oncology. It is an ancient treatment. However, when making hyperthermia we are limited by numerous biological, physical/technical and physiological problems. The word hyperthermia m...
Effects of Local and Whole Body Hyperthermia on Immunity
Gian Franco Baronzio,* Roberta Della Seta, Mario D’Amico, Attilio Baronzio, Isabel Freitas, Giorgio Forzenigo, Alberto Gramaglia and E. Dieter Hager
“Around every tumor there is a patient” – Black, Natl Cancer Inst. Monogr. 1972; 35:276. Abstract In this review, we summarized the historical and experimental basis of cancer immunity and the role of fever and of artificial elevation of temperature on immunity. The interactions of heat in vitro...
Hyperthermic Isolated Limb Perfusion
Michele De Simone* and Marco Vaira
In this overview we describe surgical procedures and hypertermic-isolated limb perfusion technique for the treatment of in transit metastases from melanoma and sarcoma of the limbs. We also briefly analyze the rationale of limb perfusion procedure. The procedures are divided, for teaching purpose...
Extreme Whole-Body Hyperthermia with Water-Filtered Infrared-A Radiation
Alexander von Ardenne and Holger Wehner
The testing of various methods to realise extreme whole-body hyperthermia (eWBH) finally led to the utilisation of radiative systems. Among these the application of water-filtered infrared-A radiation (wIRA) distinguished itself by its high penetration, all the way into the capillary bed of the s...
Vascular Effects of Localized Hyperthermia
Debra K. Kelleher and Peter Vaupel
When hyperthermia is applied in vitro, no fundamental differences can be seen between the response to normal and tumor cells. In vivo however, selective damage of tumor cells can be achieved and this phenomenon can be largely attributed to a number of characteristic properties of the blood vessel...
Influence of Tumor Microenvironment on Thermoresponse: Biologic and Clinical Implications
Gian Franco Baronzio, Alberto Gramaglia, Attilio Baronzio and Isabel Freitas
Solid tumours tend to have a more acidic and hypoxic microenvironment than normal tissue. This hostile microenvironment results from a disparity between oxygen supply and demand of the tumor tissue. Overcoming hypoxia tumor induces a new vascular supply. This new vasculature is however inefficien...
A Step Deep on Hyperthermia, Hypoxia and Chemotherapy Interactions
Giammaria Fiorentini,* Ugo De Giorgi, Maurizio Cantore, Andrea Mambrini and Stefano Guadagni
Cancer physiology can be a new significant target for therapy. Nonsurgical approaches to cancer treatment, primarily radiation therapy and chemotherapy, are almost exclusively based on agents that kill cells. The main problem with these current treatments, however, is that they do not have specif...
Hyperthermia, Physics, Vector Potential, Electromagnetic Heating: A Primer
Ugo Cerchiari
Heating methodologies of restricted and specific body volumes as means to treat cancer are critically examined from the physical point of view. Difficulties in the application of heating methodologies are considered in relation to the different means giving more space to the means more suitable f...
Hyperthermia and Radiotherapy in the Management of Prostate Cancer
Sergio Villa
Carcinoma of the prostate has been included in the top five big killer neoplasms at today. The management of advanced disease is still a problem in oncology. Starting from the begging of eighties, hyperthermia has been associated to radiotherapy with the aim to increase the local control. This i...
Hyperthermia and Angiogenesis: Results and Perspectives
Cristina Roca and Luca Primo
Hyperthermia (HT) is a promising method for cancer treatment when combined with radiotherapy or chemotherapy. The molecular mechanisms of anti-tumoral efficacy of HT are not well understood. Besides its direct cytotoxic effect on tumor cells, HT injures the normal microvasculature and, in particu...
Thermometry: Clinical Aspects and Perspectives
Barbara Biaotto and Piergiorgio Marini
Inadequate thermal dose received by the tumor can cause failures in hyperthermic treatments. In order to compare different treatments and to correlate the treatment data with the clinical results, it is mandatory to know what temperatures are reached in the target volume. From the total three dim...
Results of Hyperthermia Alone with Radiation Therapy and/or Chemotherapy
Pietro Gabriele and Cristina Roca
The interest in Clinical Hyperthermia (HT) was maximum in eighties and decreases during nineties of the last century but now, thank to possibility of heat deeply and to measure the temperature not invasively the interest is growing another time. On the other hand the biology of HT, clearly establ...
On the Biochemical Basis of Tumour Damage by Hyperthermia
P. Pietrangeli and B. Mondovi
Tumour cells are selectively inhibited by hyperthermia (41-42.5¡C) in the same conditions where normal cells are not damaged. At higher temperature, also normal cells are injured. In spite of the large number of reports on the cytotoxic effect of hyperthermia the mechanisms of heat cytotoxicity ar...
