New Vaccine Technologies
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Edited By:Ronald W. EllisShire Biologics, Inc. ISBN: 978-1-58706-050-2 Published: 2001-06-01 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
This book systematically addresses all the major available direct and enabling technologies which have contributed to the revolutionized research and development, thus improvements to existing vaccines. Its target audience is both research and development workers in the field, as well as health-care personnel who use vaccines. It should serve as an invaluable source-book in the vaccine field.
Chapters available from this book
Transcutaneous Immunization
Gregory M. Glenn
The skin is a highly complex yet well-orchestrated system committed to its protective barrier function. Human integument not only keeps moisture in and foreign material out, but is also designed for protection against the hostile microbial world which frequently gains entry through mi...
Biological Aspects and Prospects for Adjuvants and Delivery Systems
Bror Morein and Ke-Fei Hu
There is no all-encompassing definition for an adjuvant, but an old definition is: a substance that enhances the immunogenicity of coadministered antigens without !=inducing an immune response to itself. Allison and Byars1 introduced functional structures into the terminology ...
Plant-Derived Vaccines
Amanda M. Walmsely and Charles J. Arntzen
Vaccination has traveled a long road since the contents of smallpox pustules were used to inoculate individuals.1 Whilst vaccines consisting of attenuated or inactivated whole organisms are still in use, advances in recombinant DNA technology have unleashed the potential of...
DNA Vaccines
Daniel E. McCallus, Catherine J. Pachuk, Shaw-guang Lee and C. Satishchandran
Research into the use of DNA vaccines has shown that this mode of immunization has much potential for widescale application. The ability to elicit an immune response by injection of DNA encoding the gene for the protein-antigen of interest has been demonstrated by a variety of methods...
Polysaccharide Vaccines
Stephen Freese
The immune response to polysaccharide antigens is qualitatively different from that to protein antigens. Considering only those aspects that bear upon immunity to polysac- charides, the differences may be roughly described as follows. Immune cells take up and digest foreign proteins, ...
Peptide Vaccines
Damu Yang, Gregory E. Holt, Michael P. Rudolf, Markwin P. Velders, Remco M. P. Brandt, Eugene D. Kwon, and W. Martin Kast
For most of the history of vaccine production, the development of a new vaccine involved producing inactivated organisms or crude components of the pathogen. There is now generally a need to develop more precisely defined and novel vaccines against cancers and some pathogens (e.g., HIV),...
Protein-Based Vaccines
Sheena M. Loosmore, Gavin R. Zealey, and Raafat E.F. Fahim
The introduction of inactivated vaccines for viral or bacterial diseases such as smallpox, polio, pertussis, tuberculosis, measles, mumps and rubella has led to the eradication or control of these diseases. The early vaccines, though effective, were often crude and poorly characterized. ...
Live Attenuated Bacterial Vectors
Sims K. Kochi and Kevin P. Killeen
It is doubtful that Louis Pasteur could have anticipated the significance in 1881 that his discovery of bacterial attenuation would have on the use of microorganisms to protect against infectious diseases. Now, more than a century later, live attenuated bacterial vaccines have been de...
Live Attenuated Bacterial Vaccines
Kevin P. Killeen and Victor J. DiRita
Immunization is the most effective public health tool used to control infectious disease. Moreover, it is extremely cost effective given that treatment of disease is far more expensive than disease prevention. The cost of vaccines and their administration from birth to age 16 is estim...
Inactivated Virus Vaccines
Andrew D. Murdin, Benjamin Rovinski, Suryaprakash Sambhara
Inactivated virus vaccines have made a significant contribution to the control of infectious disease during the 20th century and will surely remain an important feature of vaccination strategies in the 21st century. Inactivated vaccines are currently widely avail...
Live Viral Vectors
Elizabeth B. Kauffman, Michel Bublot, Russell R. Gettig, Keith J. Limbach, Steven E Pincus, and Jill Taylor
Live viral vector vaccines derived by the insertion of genes encoding sequences from disease organisms offer a number of advantages over live attenuated vaccines, inactivated vaccines, subunit or DNA approaches. The evolution of any successful vaccine must address issues such as safet...
Recombinant Live Attenuated Viral Vaccines
Richard R. Spaete
Vaccination with live attenuated viruses in general offers a number of advantages as a strategy to evoke an effective and long lasting immune response. Foremost among these is the possibility of a nearly complete presentation of the antigenic repertoire of the pathogen to the immune s...
Live Vaccines
Alan R. Shaw
Live attenuated viral vaccines represent the most effective means of inducing a broad immune response against viruses that can be cultivated in vitro. These vaccines mimic a natural infection and thereby induce both cellular and humoral responses required for efficient defense ...
In-Licensing Issues and Vaccine Technologies
Dale R. Spriggs
The pharmaceutical industry is undergoing profound changes as the advances in biotechnology give rise to new technologies and approaches to discovering and developing new products. Conventional combinatorial chemistry and high-throughput screening combined with functional genomics, ph...
Vaccine Regulatory Issues
Marion F. Gruber, Paul G. Richman and Julianne C. M. Clifford
The fundamental goals in developing new vaccine technologies are to improve current vaccines for existing clinical indications and to develop new immunogens for both pediatric and adult use. Recent progress in the field of recombinant DNA technology and advances in basic immunology ha...
Clinical Issues for New Vaccine Technologies
Luc Hessel
Vaccination as a means of preventing infectious diseases arguably has had the greatest impact on human health of any medical intervention.1 Since the pioneer work of Jenner and Pasteur, the development of vaccines has been the consequence of the uninterrupted introduction o...
New Technologies for Making Vaccines
Ronald W. Ellis
The past two decades have witnessed an explosion in the number of technological and immunological approaches for making new vaccines. These developments have flowed from advances in a broad range of scientific fields. Some of the earliest applications of the newer technologies were to...
