Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease
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Edited By:Lazaros TriarhouUniversity of Macedonia ISBN: 978-0-306-47435-4 Published: 2002-11-15 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Directions for Future Research
Lazaros C. Triarhou
Our groundwork, first, introduced and characterized in detail the weaver mouse as a model of spontaneous progressive dopamine (DA) deficiency similar to Parkinson's disease, and secondly, laid the foundations for the intracerebral transplantation of catecholamine-producing neurons in ...
Behavioral Recovery of Functional Responses
Lazaros C. Triarhou
Studies in rats have shown that unilateral destruction of the nigrostriatal pathway by 6-hydroxydopamine (6-OHDA) results in a spontaneous rotational bias to the side ipsilateral to the lesion.1 With time, spontaneous rotational behavior subsides, but it can still be induce...
Neurochemical Indices of Functional Restoration
Lazaros C. Triarhou
A general asset of the weaver model is that one can study graft development at the same time as the animal's own dopamine (DA) system continues to undergo a progressive degeneration, which is reflected in the relatively slow loss of cells in the mutant, compared with the rapid and trauma...
Structural Correlates of Process Outgrowth and Circuit Reconstruction
Lazaros C. Triarhou
Certain cellular mechanisms by which grafts promote recovery in experimental animals have been deciphered.1,2 It has been suggested that a multitude of trophic, neurohumoral and synaptic mechanisms could be involved in bringing about functional recovery in the nigrostriatal...
Histochemical Properties of Intrastriatal Mesencephalic Grafts
Lazaros C. Triarhou
The rationale behind neural transplantation studies using the weaver mouse model has been to replace degenerated neurons that are lost in the neurogenetic disease by intracerebrally grafted fetal mesencephalic cells.1 The cellular properties of dopaminergic grafts had been stu...
Biology and Pathology of the Weaver Mutant Mouse
Lazaros C. Triarhou
The weaver mutant mouse (wv/wv) is characterized by a genetically-induced degeneration of mesostriatal dopamine (DA) neurons. In that sense, it can be viewed as a pathophysiological phenocopy of Parkinsonism and, therefore, an invaluable experimental model for investigating mechanisms...
Introduction
Lazaros C. Triarhou
Dopamine and Parkinson's Disease
Movement control is accomplished by complex interactions among various groups of nerve cells in the central nervous system. One such important group ofneurons is located in the substantia nigra in the ventral midbrain. Nigral neurons give rise to an ...
