Support of the Acutely Failing Liver
Second Edition
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Edited By:Achilles A. DemetriouCedars-Sinai Medical Center
Frederick D. Watanabe Published: 1999-11-01 |
In this book, members of the Cedars-Sinai Medical Center, Liver Support Unit (LSU) present the most current understanding of the pathophysiology of liver failure and how its various forms and manifestations are classified, and summarize the state of the art in the diagnosis and management of the disease.
Chapters available from this book
Other Experimental Therapeutic Strategies: Hepatocyte Transplantation
Helene Lilja, Nikolaos Arkadopoulos, Susumu Eguchi
Transplantation of hepatocytes, injection of various hepatocyte extracts and hepatocyte culture supernatants, have been shown to prolong survival in animals with D,(+)–galactosamine–induced liver injury and animals with acute liver ischemia.1–3 Hepatocyte tra...
Other Experimental Therapeutic Strategies: Liver Gene Therapy
Jacek Rozga, Helen Lilja, Walid Arnaout, Achilles A. Demetriou
Somatic human gene therapy has been a topic of surging interest during the last several years. Initial results of experiments altering transformed cell lines to produce foreign gene products appeared promising. Early gene therapy techniques utilized naked DNA transfer and had limited ...
Development of a Strategy for Management of Severe Acute Liver Failure: The Liver Support Unit
Achilles A. Demetriou, Frederick D. Watanabe
As we have repeatedly emphasized throughout this monograph, severe acute liver failure (SALF) is associated with very high morbidity and mortality and represents one of the most challenging problems in clinical medicine. Historically, when faced with complex clinical problems, the medica...
Clinical Use of a Bioartificial Liver to Treat Acetaminophen-Induced Fulminant Hepatic Failure
Olivier Detry, Nikolaos Arkadopoulos, Elaine Kahaku, Frederick D. Watanabe, Jacek Rozga, Achilles A. Demetriou
Acetaminophen toxicity may cause massive hepatocellular necrosis leading to fulminant hepatic failure (FHF).1,2 In acetaminophen-induced FHF patients, prognosis can be accurately assessed using criteria defined by the King's College Hospital (KCH) group.3 Accordi...
Clinical Experience with a Bioartificial Liver
Frederick D. Watanabe, Elaine Kahaku, Theodore Khalili, Paul Ting, Anthony, Anthony Navarro, Achilles A. Demetriou
In spite of substantial advances in general supportive therapy and critical care, mortality in fulminant hepatic failure (FHF) remains unacceptably high, due primarily to incomplete understanding of the pathophysiology of the disease.1 Despite this, clinicians have attempte...
Liver Support System Development
Jacek Rozga, Kyung.S. Suh, Helene Lilja, Walid S. Arnaout, Achilles A. Demetriou
For many years it has been assumed that the majority of toxins which cause coma in hepatic failure are small dialyzable molecules. As a result, most liver support systems and therapeutic regimens relied primarily on blood detoxification. However, the pathogenesis of acute liver failure i...
Surgical Management of Acute Liver Failure
Walid S. Arnaout, David Reybould
Fulminant hepatic failure (FHF) continues to be one of the most devastating conditions affecting thousands of individuals each year. By definition, these are patients who were previously healthy without any known underlying liver disease. Historically, the outcome of these patients in...
Medical Management of Acute Liver Failure
Frederick D. Watanabe, Elaine Kahaku, Achilles A. Demetriou
Despite advances in critical care management, prognosis in fulminant liver failure (FHF) remains poor, with mortality between 70 and 90%.1 Introduction of orthotopic liver transplantation has improved outcome and increased patient survival. The paradigm of medical management o...
Acute Hepatic Encephalopathy: Treatment
Olivier Detry, Jody E. Margulies, Nicholas Arkadopoulos, Achilles A. Demetriou
Intracranial hypertension secondary to brain edema is the most common cause of death in fulminant hepatic failure (FHF) patients, even when they are listed for urgent orthotopic liver transplantation (OLT).1 Brain edema is a complication of FHF. In a 1944 report of 125 autopsi...
Acute Hepatic Encephalopathy: Pathophysiology and Diagnosis
Steven D. Colquhoun, Caroline A. Connelly
Hepatic encephalopathy is a neuropsychiatric syndrome that refers to potentially reversible derangement of thought and behavior which accompany liver disease.1 Although there may be significant overlap in symptoms and etiology, both liver disease and hepatic encephalopathy can...
Acute Liver Failure: Definitions and Etiology
Donna E. Goldman, Graham M. Woolf
In the United States, there are approximately 2000 cases/year of acute hepatic failure (AHF) in adults and children.1 The term "fulminant hepatitis" was introduced by Lucke and Mallory in 1948 to describe posttransfusion hepatitis in soldiers dying within 9 days of the onset o...
The Liver: A Brief Historical Perspective
Elaine Kahaku
The United Nations has recommended standardized dating using BCE, for 'before the common era', instead of BC and CE, for 'common era', instead of AD.
Throughout history, man has striven to understand the liver's function and disorders. Early representations of the liver were seen...
