Oral Tolerance: The Response of the Intestinal Mucosa to Dietary Antigens
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Edited By:Olivier MorteauHarvard University ISBN: 978-0-306-47989-2 Published: 2004-07-27 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Clinical Applications of Oral Tolerance
Howard L. Weiner
Oral tolerance has classically been defined as the specific suppression of cellular and/or humoral immune responses to an antigen by prior administration of the antigen by the oral route. It presumably evolved to prevent hypersensitivity reactions to food proteins and bacterial antigens present i...
Physiopathology of Celiac Disease
Katri Kaukinen, Markku Meki and Pekka Collin
In celiac disease, ingestion of gluten results in T-cell-mediated small bowel mucosal damage characterized by subtotal or severe partial villous atrophy with crypt hyperplasia. A life-long gluten-free diet is essential to clinical and small bowel mucosal recovery, and for prevention of complicati...
Food and Milk Allergies
Mary H. Perdue and Martine Heyman
Oral tolerance is the usual response to antigens encountered via the gut mucosal immune system. However in some individuals, ingestion of food antigens does not result in a down-regulated system, but rather an immunologically-mediated allergic reaction. Such reactions occur in ~2-5% of the popula...
Induction of Tolerogenic versus Pathogenic Mucosal Immune Responses by Commensal Enteric Bacteria
Dirk Haller and R. Balfour Sartor
Inflammatory bowel diseases (IBD) including ulcerative colitis (UC) and Crohn’s disease (CD) are spontaneously relapsing, immunologically-mediated disorders of the gastrointestinal tract. Microbial agents are intimately involved in each of the four major current etiologic theories of these idiopa...
IgA and Mucosal Homeostasis
Jesper Reinholdt and Steffen Husby
Mucosal surfaces represent the major interface between host and environment. They constitute the point of entry of most infectious pathogens, and are in contact with potentially injurious antigens present in the normal mucosal microflora and in ingested or inhaled substances. To deal appropriatel...
Cytokines, Cyclooxygenases and Oral Tolerance
Olivier Morteau
The intestinal mucosa faces a perpetual challenge: to allow the entry of minerals and nutrients from the lumen while modulating the immune responses to luminal antigens, in order to prevent mucosal inflammation. The immunosuppressive response of the mucosa to food antigens and bacteria of the nor...
The Role of T Cells in the Intestinal Mucosa
Giovanni Monteleone and Thomas T. MacDonald
The intestine contains the largest population of T cells in the body. This reflects the fact that the intestine has a large surface area continuously exposed to dietary antigens and microorganisms. The gut immune system is therefore fundamentally different from the systemic immune system in that ...
A Revisit of Current Dogma for the Cellular and Molecular Basis of Oral Tolerance
Kohtaro Fujihashi, Hirotomo Kato and Jerry R. McGhee
Studies of the cellular and molecular mechanisms for oral tolerance have focused on the central importance of CD4+ T cells and their surface co-stimulatory molecules as well as derived cytokines. In addition ?? T cells play critical roles in the induction of mucosally (orally and nasally) induced...
Oral Tolerance: An Overview
Allan McI Mowat
The diet of all animals contains a wide variety of proteins of animal and vegetable origin, most of which are potentially antigenic. Contrary to much popular belief, a significant proportion of this material is absorbed in an immunologically intact form, generating intact protein and/or protein f...
Structure and Function of the Gastrointestinal Mucosa
Mona Bajaj-Elliott and Ian R. Sanderson
The large mucosal surface of the gastrointestinal tract faces many challenges while maintaining overall body metabolic integrity.1,2 The primary function of the small intestine is to digest and absorb essential nutrients from the complex milieu of the gut lumen into the circulation.3 The mucosal ...
