Molecular Biology of the Parathyroid
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Edited By:Tally Naveh-ManyHadassah University ISBN: 978-0-306-47847-5 Published: 2005-01-11 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Skeletal and Reproductive Abnormalities in Pth-Null Mice
Dengshun Miao, Bin He, Beate Lanske, Xiu-Ying Bai, Xin-Kang Tong, Geoffrey N. Hendy, David Goltzman and Andrew C. Karaplis
We have examined the role of parathyroid hormone (PTH) in the postnatal state in a mouse model of PTH-deficiency generated by targeting the Pth gene in ES cells. Mice homozygous for the ablated allele, when maintained on a normal calcium intake, developed hypocalcemia, hyperphosphatemia, and low ...
Genetic Causes of Hypoparathyroidism
Rachel I. Gafni and Michael A. Levine
Hypoparathyroidism is characterized clinically by the presence of hypocalcemia and hyperphosphatemia due to inadequate supply or effectiveness of circulating parathyroid hormone (PTH). It may be present either as an isolated finding or as a component of a more complex developmental, metabolic, or...
Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism
Trisha M. Shattuck, Sanjay M. Mallya and Andrew Arnold
The biochemical state of primary hyperparathyroidism is generally caused by hypercellular parathyroid glands categorized as multigland hyperplasia, benign adenoma or malignant carcinoma. Most, and probably all, adenomas and carcinomas are monoclonal in origin, and specific clonal genetic lesions ...
Molecular Mechanisms in Parathyroid Tumorigenesis
Eitan Friedman
Primary hyperparathyroidism (1 HPT) is a relatively common disorder, with an estimated prevalence of 1:500-1:1000.1 In about 80%-85% of 1 HPT cases, a single enlarged parathyroid gland with a distinct capsule that separates the tumorous from the nontumorous tissue (=adenoma or uniglandular diseas...
Parathyroid Gland Hyperplasia in Renal Failure
Adriana S. Dusso, Mario Cozzolino and Eduardo Slatopolsky
Secondary hyperparathyroidism, a frequent complication of chronic renal failure, is characterized by parathyroid hyperplasia and enhanced synthesis and secretion of parathyroid hormone (PTH).1-3 As summarized in Figure 1, high circulating PTH levels are not only a major contributor to osteitis fi...
Vitamin D Analogs for the Treatment of Secondary Hyperparathyroidism in Chronic Renal Failure
Alex J. Brown
Secondary hyperparathyroidism (2oHPT) is a common complication in patients with chronic renal failure. The pathogenesis of 2oHPT is attributed primarily to phosphate retention and low serum 1,25(OH)2D3. Replacement therapy with calcitriol [1,25-dihydroxyvitamin D3 or 1,25(OH)2D3] or its precursor...
Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D
Tally Naveh-Many and Justin Silver
Vitamin D’s active metabolite 1,25(OH)2D3 acts on the parathyroid to markedly decrease PTH gene transcription. It does this by binding to its specific receptor in the parathyroid which then binds to a defined sequence, the vitamin D response element (VDRE) in the parathyroid hormone (PTH) gene pr...
In Silico Analysis of Regulatory Sequences in the Human Parathyroid Hormone Gene
Alexander Kel, Maurice Scheer and Hubert Mayer
Parathyroid hormone (PTH) is intimately involved in the homeostasis of normal serum concentrations of calcium and phosphate, which, in turn, regulate the synthesis and secretion of PTH. The synthesis and secretion of PTH in the parathyroid gland is regulated at the transcriptional, posttranscript...
Regulation of Parathyroid Hormone mRNA Stability by Calcium and Phosphate
Rachel Kilav, Justin Silver and Tally Naveh-Many
Calcium and phosphate regulate parathyroid hormone (PTH) secretion, gene expression and if prolonged also parathyroid proliferation. The regulation of PTH gene expression by Ca2+ and Pi is post-transcriptional, affecting mRNA stability. The regulation of PTH mRNA stability is mediated by the bind...
The Calcium Sensing Receptor
Shozo Yano and Edward M. Brown
The acute secretory response of parathyroid hormone (PTH) is strictly regulated by the extracellular calcium concentration (Ca2+ o), and the G protein-coupled, calcium-sensing receptor (CaR) located on the chief cells of the parathyroid glands mediates this process. Abnormalities of the Ca2+ o-...
Toward an Understanding of Human Parathyroid Hormone Structure and Function
Lei Jin, Armen H. Tashjian, Jr., and Faming Zhang
Parathyroid hormone (PTH) is synthesized as a 115 amino acid precursor and secreted as an 84 amino acid polypeptide that regulates extracellular calcium homeostasis via actions directly on kidney and bone and indirectly on the intestine by facilitating calcium absorption.1 PTH and a related molec...
Parathyroid Hormone, from Gene to Protein
Osnat Bell, Justin Silver and Tally Naveh-Many
The biosynthetic pathway of parathyroid hormone (PTH) has been studied from gene expression to PTH intracellular processing.1 The processing of PTH has been described and involves the synthesis of an initial translational product, preProPTH, and two proteolytic cleavages that in turn produce ProP...
Development of Parathyroid Glands
Thomas Gunther and Gerard Karsenty
The parathyroid glands (PG) are the main source for circulating parathyroid hormone (PTH), a hormone that is essential for the regulation of calcium and phosphate metabolism. The PGs develop during embryogenesis from the pharyngeal pouches with contributions from endodermal and neural crest cells...
