Viral Genome Packaging Machines: Genetics, Structure
and Mechanism
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Edited By:Carlos CatalanoUniversity of Colorado ISBN: 978-0-306-48227-4 Published: 2005-04-15 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
This book includes 6 color images.
Chapters available from this book
Bacteriophage SPP1 DNA Packaging
Anja Droge and Paulo Tavares
SPP1 is a virulent double-stranded DNA (dsDNA) phage that infects the Gram-positive bacterium Bacillus subtilis strain 168. SPP1 belongs to the Siphoviridae family. The virion is composed of an icosahedral, isometric capsid (~60 nm diameter) and a long, flexible, noncontractile tail.1 The phage h...
DNA Packaging in Bacteriophage T4
Venigalla B. Rao and Lindsay W. Black
Double-stranded (ds) DNA packaging in phage T4 and other icosahedral viruses is a fascinating biological problem. During packaging, a complex, metabolically active, concatemeric DNA is translocated into an empty prohead in an ATP-driven process and condensed as a highly ordered structure of near ...
Bacteriophage Lambda Terminase and the Mechanism of Viral DNA Packaging
Michael Feiss and Carlos Enrique Catalano
The developmental pathways of many double-stranded DNA (dsDNA) viruses, both prokaryotic and eukaryotic, are remarkably similar. In viruses as diverse as bacteriophage λ and the herpesviruses, DNA replication proceeds through a rolling circle mechanism where the circular genome serves as a t...
The o29 DNA Packaging Motor: Seeking the Mechanism
Dwight Anderson and Shelley Grimes
The Bacillus subtilis bacteriophage o29 research team in Minneapolis has marveled at (and reveled in) the intricacies of o29 assembly for more than 30 years. Here we highlight the current state of knowledge of o29 DNA packaging. We describe the in vitro packaging system and focus on recent advanc...
Bacteriophage SPP1 DNA Packaging
Anja Dr?ge and Paulo Tavares
SPP1 is a virulent double-stranded DNA (dsDNA) phage that infects the Gram-positive bacterium Bacillus subtilis strain 168. SPP1 belongs to the Siphoviridae family. The virion is composed of an icosahedral, isometric capsid (~60 nm diameter) and a long, flexible, noncontractile tail.1 The phage h...
DNA Packaging by Bacteriophage P22
Sherwood Casjens and Peter Weigele
Bacteriophage P22 was isolated by Zinder and Lederberg1 a half century ago, and was immediately put to work by Salmonella bacterial geneticists because of its unusual (at that time) DNA packaging properties. It was the first generalized transducing phage to be discovered – a small fraction (~2%2)...
Cleavage and Packaging of Herpes Simplex Virus 1 DNA Herpesvirus Assembly
Joel D. Baines and Sandra K. Weller
Herpes simplex virus DNA accumulates in the nuclei of infected cells as long concatemers. The packaging machinery recognizes signals within the concatemers, cleaves the DNA to generate unit length monomers, and inserts the cleaved genomes into preformed capsids. The goals of this work are to revi...
Encapsidation of the Segmented Double-Stranded RNA Genome of Bacteriophage PHI 6
Minna M. Poranen, Markus J. Pirttimaa and Dennis H. Bamford
Bacteriophage PHI6 has a segmented double-stranded RNA genome that is incorporated into a preformed capsid during the viral assembly. The three viral genomic segments are packaged as single-stranded precursors, which are later replicated into the mature double-stranded genome inside the capsid by...
T3/T7 DNA Packaging
Philip Serwer
During formation of a mature bacteriophage particle, a procapsid of protein packages the linear double-stranded DNA genome of the related bacteriophages, T3 and T7. Initiation of T3/T7 DNA packaging in vivo occurs near the genetic right end of a concatemer-associated genome. Initiation in vivo re...
