Reactivation of the Cell Cycle in Terminally Differentiated Cells
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Edited By:Marco CrescenziIstituto Superiore di Sanita ISBN: 978-0-306-47423-1 Published: 2003-01-25 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Terminal differentiation is defined as the state in which a cell has acquired specialized properties and has ceased proliferating permanently. This book comprehensively describes whether the terminally differentiated state actually exists, the molecular mechanisms that control the post-mitotic state, and whether terminally differentiated cells can be induced to proliferate in a stable, controllable and reversible fashion.
Chapters available from this book
Reversal of Terminally Differentiated State in Skeletal Myocytes by SV40 Large T Antigen
Takeshi Endo
Terminal differentiation of mammalian skeletal muscle cells had long been thought to result in irreversible arrest in G0 phase of the cell cycle. Such terminally differentiated myotubes are refractory to apoptosis. However, I show here, using the SV40 large T...
Cellular Dedifferentiation During Regeneration: The Amphibian Muscle System
Elly Tanaka
Amphibian limb regeneration represents a striking system where the reversal of muscle cell differentiation occurs in response to physiological stimuli. During this process, dedifferentiation is used to form progenitor cells for tissue repair. In response to injury, m...
Cell Cycle Reactivation in Skeletal Muscle and Other Terminally Differentiated Cells
Alessandra Sacco, Deborah Pajalunga, Lucia Latella, Francesca Siepi, Alessandro Rufini and Marco Crescenzi
This Chapter reviews, in a historical perspective, our current understanding of the cell cycle control in terminally differentiated skeletal muscle cells. Attempts at inducing reentry into the cell cycle and proliferation of terminally differentiated muscle cells are re...
Regulation of Cardiomyocyte Proliferation and Apoptosis
Kishore B.S. Pasumarthi, Adil I. Daud and Loren J. Field
Myocardial function is compromised in several forms of heart disease due to the loss of cardiomyocytes and in part to the limited ability of surviving myocytes to re–enter the cell cycle. The ability to induce cardiomyocyte proliferation will improve myocardial fun...
Myocyte Proliferation in Heart Failure
Jan Kajstura, Annarosa Leri, Antonio Beltrami, Carlo A. Beltrami, Edmund H. Sonnenblick and Piero Anversa
The results summarized in this short Chapter challenge the perennial dogma that cardiac myocytes are terminally differentiated cells. Unequivocal evidence of mitosis is provided in the pathologic human heart and in animal models mimicking the human disease. Additiona...
