Cell-Cycle Mechanisms and Neuronal Cell Death
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Edited By:Agata CopaniUniversity of Catania Catania, Italy Ferdinando Nicoletti University of Rome "La Sapienza" Rome, Italy and I.N.M. Neuromed Pozzilli, Italy ISBN: 978-0-306-47850-5 Published: 2005-08-05 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Alzheimer Disease: A New Beginning or a Final Exit?
Mark E. Obrenovich, Arun K. Raina, Osamu Ogawa, Craig S. Atwood, Laura Morelli and Mark A. Smith
Today, a new chapter is being written in the book of Alzheimer disease, one that is challenging the longstanding view that adult neurons are incapable of division, remain nonproliferative, and are terminally differentiated. Here, we review the provocative notion that, in Alzheimer disease, whole ...
Cell Cycle Activation in Neurons: The Final Exit of Brain Morpho-Dysregulation
Thomas Arendt
Mammalien cells act and react within frameworks of defined cellular programmes such as division, movement, adhesion, differentiation and death, integrating both genetic and epigenetic information. Execution of these programmes, ones activated, are surprisingly stable, even under pathological cond...
Cell Cycle and Chromosome Segregation Defects in Alzheimer’s Disease
Huntington Potter
Despite a common set of hallmark neuropathological lesions and clinical symptoms, Alzheimer’s disease has an apparently complex etiology. The disease can be caused by autosomal dominant mutations in at least three genes (encoding the amyloid precursor protein (APP) and the two presenilins). In ad...
Cell Cycle Activation and Cell Death in the Nervous System
Zsuzsanna Nagy
The discovery of the cell division cycle opened new avenues for the understanding of cancer as well as in the search for therapy. However, the implications of the discovery had a more profound effect on biological research than anticipated at the time. We can now clearly distinguish between the a...
The Role of Presenilins in the Cell Cycle and Apoptosis
Mervyn J. Monteiro
Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, affecting approximately 10% of individuals by 65 years of age and 47% by 85 years of age. Whereas the majority of AD cases appear to be sporadic, and occur in individuals that have no apparent family history, a small pe...
Paved with Good Intentions: The Link Between Cell Cycle and Cell Death in the Mammalian Central Nervous System
Yan Yang and Karl Herrup
Cell division is among the most basic of biological processes. All life forms, from blue-green algae to human hepatocytes, ultimately depend for their survival on the ability of one cell to create two. In keeping with the centrality of this process, the component enzyme systems have been well con...
Alzheimer Disease—A New Beginning, or a Final Exit?
Mark E. Obrenovich, Arun K. Raina, Osamu Ogawa, Craig S. Atwood, Laura Morelli and Mark A. Smith
Today, a new chapter is being written in the book of Alzheimer disease, one that is challenging the longstanding view that adult neurons are incapable of division, remain nonproliferative, and are terminally differentiated. Here, we review the provocative notion that, in Alzheimer diseas...
