Hematopoietic Stem Cell Development
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Edited By:Isabelle GodinInstitut Gustave Roussy Villejuif, France Ana Cumano Institut Pasteur Paris, France ISBN: 978-0-306-47872-7 Published: 2006-02-16 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Hematopoietic Stem Cells brings together articles covering the biology of hematopoietic stem cells during embryonic development, reporting particular aspects of fly, fish, avian and mammalian models. Thus, this book allows a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing the conserved trends in development. This book culminates with state-of –the art knowledge on hematopoietic development in human species and discussions of the most recent breakthroughs with relevance to both researchers and clinicians.
Chapters available from this book
Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo
Julien Yuan Bertrand, Alexandra Manaia, Jeanne Van Celst, Ana Cumano and Isabelle Godin
The hematopoietic system comprises a large array of differentiated cells (lymphocytes, myeloid cells, erythrocytes, etc…) with a limited half-life. The hematopoietic com- partment thus depends on a continuous renewal throughout life. In adult mammals, mature blood cells are constantly generat...
Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem Cell Differentiation
Jussi Liippo* and Olli Lassila
Hematopoiesis starts in the yolk sac blood islands and in a region of dorsal aorta in the early embryo. Interest in the emergence of the hematopoietic stem cells in the embryo proper has increased in last years. In an avian model the primitive erythropoiesis derived from extraembryonic yolk sac i...
Long-Term Reconstituting Hematopoietic Stem Cell Capacity of the Embryo
Mervin C. Yoder
Hematopoiesis is the dynamic process whereby all formed elements of the blood arise from multipotent precursor cells. In the adult mouse, hematopoiesis occurs primarily within the medullary cavity of bone and in the spleen. During murine development, however, hematopoiesis is found in numerous si...
Yolk Sac Development in Mice
James Palis
A functional cardiovascular system is essential for survival and growth of the mammalian embryo, so the hematopoietic, vascular, and cardiac organ systems are the first to emerge in early post-implantation development.1 During gastrulation, mesoderm cells create the body plan, forming red blood c...
Intraembryonic Development of Hematopoietic Stem Cells During Human Ontogeny Expression Analysis
Caroline Marshall
The adult hematopoietic system is composed of a number of different cell types, including erythrocytes and cells of the myeloid and lymphoid lineages. It is generally believed that all these cell types derive, through a series of maturing progenitors, from a common stem cell, which first appears ...
Endothelial and Hematopoietic Cells in the Intra-Embryonic Compartment
Fumio Arai and Toshio Suda
The development of endothelial cells and hematopoietic cells is closely related at embryonic stages, and both cells share a common precursor, the hemangioblast. Differentiation into hematopoietic and endothelial lineages begins with proliferation of a single layer of mesodermal cells in the yolk ...
The Endothelium—The Cradle of Definitive Hematopoiesis?
Katrin Ottersbach and Elaine Dzierzak
It has been more than 80 years since a lineage relationship between hematopoietic and endothelial cells in the form of a bipotential precursor – the hemangioblast – was first proposed. Evidence has accumulated that supports the existence of such a cell, however, identification and isolation o...
Hematopoietic Development in Drosophila: A Parallel with Vertebrates
Marie Meister and Shubha Govind
Drosophila hematopoiesis includes two distinct phases. The first phase occurs during the second half of embryonic development, whereas the second hematopoietic phase occurs during the larval stages. Blood cells (hemocytes) are responsible mainly for phagocytosis, encapsulation of large invader...
Gene and Cell Therapy Involving Hematopoietic Stem Cell
Isabelle André-Schmutz and Marina Cavazzana-Calvo
Hematopoietic Stem Cells (HSC) possess two characteristics, long term self-renewal capacity and pluripotentiality, that render them able to develop into the different blood cell lineages. HSC transplantations (HSCT) have thus been used to reconstitute hematopoiesis after myeloablation for more...
Extra and Intraembryonic HSC Commitment in the Avian Model
T. Jaffredo, K. Bollerot, K. Minko, R. Gautier, S. Romero and C. Drevon
Hematopoietic Stem Cells (HSC) are at the basis of the hematopoietic system con- struction. In adult higher Vertebrates, HSC, defined by their multipotentiality and self-renewal capacity, settle in the bone marrow where they can differentiate into progenitors with more restricted lineage potent...
Genetic Dissection of Hematopoiesis Using the Zebrafish
Rebecca A. Wingert and Leonard I. Zon
Hematopoiesis during embryogenesis and adult life has been extensively studied in several vertebrate models. The zebrafish (Danio rerio) has recently provided a power- ful genetic system to further dissect the molecular pathways of hematopoiesis. Large-scale genetic screens utilizing the zebraf...
Ventral and Dorsal Contributions to Hematopoiesis in Xenopus
Aldo Ciau-Uitz, Maggie Walmsley and Roger Patient
The view that all blood derives from ventral mesoderm has been challenged in recent years. In the Xenopus embryo, it is now clear that the embryonic blood compartment, the ventral blood island (VBI), is derived from regions of the pre-gastrula embryo traditionally referred to as dorsal as wel...
