Immune Mechanisms of Allergic Contact Dermatitis
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Edited By:Andrea CavaniIstituto Dermopatico dell'Immacolata - Rome ISBN: 978-1-58706-209-4 Published: 2005-01-10 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Evidence-Based Answers to Clinical Questions in Allergic Contact Dermatitis
Whitney A. High and Ponciano D. Cruz
Four issues of current relevance to clinical contact dermatitis are discussed in the context of basic knowledge regarding immunopathogenesis: What differentiates contact allergens from contact irritants? What governs sensitization versus tolerance? How does patch test reactivity relate to disease...
Cytokines in Contact Sensitivity
Alexander H. Enk
Allergic contact dermatitis (ACD) is one of the best-established model diseases for T cell-mediated immune responses. Besides the important role that T cells play in the initiation and maintenance of this immune response, cytokines have been shown to be important mediators of the inflammatory pro...
Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Receptor
Hans Ulrich Weltzien, Andrea Detze, Katharina Gamerdinger, Sven Hellwig, and Hermann-Josef Thierse
Haptens as low molecular chemicals compose a major percentage of the universe of allergens, particularly with respect to allergic contact dermatitis (ACD). They are usually defined as compounds which only upon covalent interaction with proteins acquire the potential to induce hapten-specific B ce...
T Cell Subsets in Allergic Contact Dermatitis
Andrea Cavani, Francesca Nasorri and Giampiero Girolomoni
Allergic contact dermatitis is the result of an exaggerated immune response sustained by CD8+ and CD4+ type 1 T lymphocytes towards small chemicals penetrating through the skin. Expression of the disease depends upon a coordinated series of events, which include leukocyte extravasation and positi...
Approaches to the Predictive Identification and Assessment of Chemical Contact Allergens
David A. Basketter, Grace Y. Patlewicz, Camilla K. Smith Pease, Nicola Gilmour and Ian Kimber
The prospective identification of potential contact allergens and their subsequent safety assessment is the pivotal activity in successful management of this risk to human health. Although much can be learned from the chemical and physical properties of a substance, the definitive information in ...
A Dual Role for Mast Cells in Contact Hypersensitivity Reactions More Team Players in Type 1 T Cell Mediated Contact Hypersensitivity Reactions
Tilo Biedermann and Martin R?cken
Contact hypersensitivity reactions (CHSR) are prototypic delayed type hypersensitivity reactions (DTHR). They are mediated by interferon (IFN)?-producing CD4+ and CD8+, which are called type 1 T cells. Type 1 T cells can lead to the development of CHSR if directed against haptens or to autoimmune...
T Cell Recruitment in Allergic Contact Dermatitis
Silvia Sebastiani, Giampiero Girolomoni and Andrea Cavani
Expression of allergic contact dermatitis requires efficient recruitment of T cells and other leukocytes at the site of penetration of haptens. The ability of T cells to circulate in the skin environment is defined by their homing and chemokine receptor asset, and is directed by the chemokine rep...
Contribution of CD4+ and CD8+ T Cells in Contact Hypersensitivity and Allergic Contact Dermatitis
Pierre Saint-Mezard, Fr_d_ric B_rard, Bertrand Dubois
Allergic contact dermatitis (ACD) and contact hypersensitivity (CHS) are delayed-type hypersensitivity reactions which are mediated by hapten specific T cells. During the sensitisation phases, both CD4+ and CD8+ T cell precursors are activated in the draining lymph nodes by presentation of hapten...
The Use of Gene-Targeted Mice in Contact Hypersensitivity Research
Binghe Wang, Brandon G Howell, Adam J Mamelak and Daniel N Sauder
Contact hypersensitivity (CHS), clinically presenting as allergic contact dermatitis, is a T cell-mediated cutaneous immune inflammatory response to reactive haptens. Al though CHS is generally thought of as a Langerhans cell-dependent, Th1 type immune reaction, much is unknown about the complica...
Langerhans Cell Migration and the Induction Phase of Skin Sensitization
Marie Cumberbatch, Rebecca J. Dearman, Christopher E.M. Griffiths, Richard W. Groves and Ian Kimber
Langerhans cells (LC) are members of a wide family of bone marrow derived, immunoactive dendritic cells (DC). LC reside in the epidermis where they are regarded as sentinels of the adaptive immune system with responsibility for surveying changes in the microenvi-ronment and forming a trap for extern...
Dendritic Cells As a Target for Therapeutic Intervention of Contact Hypersensitivity
Akira Takashima, Hiroyuki Matsue, Tadashi Kumamoto, Norikatsu Mizumoto, Akimichi Morita and Mark E. Mummert
Langerhans cells (LC), a skin-specific member of the dendritic cell (DC) family of antigen presenting cells, play crucial roles in the induction of allergic contact hypersensitivity responses (CHSR). Skin exposure to reactive haptens causes LC emigration from the epidermis as well as their matura...
Animal Models of OXPHOS Disorders
Nicole Hance and Nils-G?ran Larsson
Dysfunction of the mitochondrial respiratory chain has been associated with a wide range of human diseases ranging from diabetes to cardiomyopathy. Mutations in a number of nuclear as well as mitochondrial genes have been implicated in causing these diseases. Several animal models have now been c...
Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Receptor
Hans Ulrich Weltzien, Andrea D?tze, Katharina Gamerdinger, Sven Hellwig, and Hermann-Josef Thierse
Haptens as low molecular chemicals compose a major percentage of the universe of allergens, particularly with respect to allergic contact dermatitis (ACD). They are usually defined as compounds which only upon covalent interaction with proteins acquire the potential to induce hapten-specific B ce...
T Cell Subsets in Allergic Contact Dermatitis
Andrea Cavani, Francesca Nasorri and Giampiero Girolomoni
Allergic contact dermatitis is the result of an exaggerated immune response sustained by CD8+ and CD4+ type 1 T lymphocytes towards small chemicals penetrating through the skin. Expression of the disease depends upon a coordinated series of events, which include leukocyte extravasation and pos...
UVB Radiation and Modulation of T Cell Responses to Haptens
Thomas Schwarz, Stefan Beissert and Agatha Schwarz
Ultraviolet B (UVB) radiation exerts a variety of biological effects, including premature skin ageing, induction of skin cancer and suppression of immune responses. The implications of the immunosuppressive properties of UVB radiation are severalfold since UVB-induced immunosuppression of the ...
