Brain Repair
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Edited By:Mathias BährUniversität Tübingen ISBN: 978-0-306-47859-8 Published: 2005-09-20 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Transplantation in Parkinson’s Disease: The Future Looks Bright
Gesine Paul, Young Hwan Ahn, Jia-Yi Li and Patrik Brundin
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects almost 1% of the population above the age of 50. Early in the course of the disease, patients primarily display motor symptoms, including bradykinesia, rigidity and resting tremor.119,120 These symptoms wors...
The Collagenous Wound Healing Scar in the Injured Central Nervous System Inhibits Axonal Regeneration
Susanne Hermanns, Nicole Klapka, Marcia Gasis and Hans Werner Muller
Following traumatic injuries of the central nervous system (CNS) a wound healing scar, resembling the molecular structure of a basement membrane and mainly composed of Collagen type IV and associated glycoproteins and proteoglycans, is formed. It is well known that CNS fibers poorly regenerate af...
Neuroprotection by cAMP: Another Brick in the Wall
Mariana S. Silveira and Rafael Linden
Programmed cell death occurs in the nervous system both in normal development as well as in pathologic conditions, and is a key issue related to both brain repair and neurodegenerative diseases. Modulation of cell death in the nervous system may involve neurotrophic factors and other peptides, ne...
The Role of Ionotropic Purinergic Receptors (P2X) in Mediating Plasticity Responses in the Central Nervous System
F. Florenzano, M.T. Viscomi, F. Cavaliere, C. Volonti, M. Molinari
The past few years have witnessed increasing interest in the field of purinergic signalling and have recognised ATP as an extracellular messenger eliciting a wide array of physi ological effects in several different tissues. These effects range from simple biological events such as neurotransmiss...
The Glial Response to Injury and Its Role in the Inhibition of CNS Repair
James W. Fawcett
The failure of axon regeneration after CNS injury is due to an inadequate or inappropri ate regenerative response from damaged CNS axons, and to a CNS environment that inhibits regeneration. This inhibitory environment contains many molecules that promote axon growth as well as molecules that inh...
DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms During Development and Regeneration of Neural Tissues
Andreas Faissner, Nicolas Heck, Alexandre Dobbertin and Jeremy Garwood
Interactions between neurons and glial cells play important roles in regulating key events of development and regeneration of the CNS. Thus, migrating neurons are partly guided by radial glia to their target, and glial scaffolds direct the growth and directional choice of advancing axons, e.g., a...
A Kinase with a Vision: Role of ERK in the Synaptic Plasticity of the Visual Cortex
Gian Michele Ratto and Tommaso Pizzorusso
We look at these written words with two eyes, their neuronal representations are elabo rated separately in the two retinae and they are conveyed to two separate zones of the thalamus. The segregation in eye specific structures is broken only in the primary visual cortex, where neurons respons...
Lesion-Induced Axonal Sprouting in the Central Nervous System
Thomas Deller, Carola A. Haas, Thomas M. Freiman, Amie Phinney, Mathias Jucker and Michael Frotscher
Injury or neuronal death often come about as a result of brain disorders. Inasmuch as the damaged nerve cells are interconnected via projections to other regions of the brain, such lesions lead to axonal loss in distal target areas. The central nervous system responds to deafferentation by mea...
Cell Death in the Nervous System
Kerstin Krieglstein
Programmed cell death is a fundamental and essential process in development and tissue homeostasis of multicellular organisms. About half of all neurons produced during neurogenesis die before the nervous system matures. Failure to kill appropriate cells can lead to severe developmental defect...
Role of Endogenous Neural Stem Cells in Neurological Disease and Brain Repair
Jörg Dietrich and Gerd Kempermann
There is abundant evidence that neural stem cells persist in the adult mammalian brain – including humans – throughout lifetime and support ongoing neurogenesis in re- stricted regions of the central nervous system (CNS). The potential role of neural stem cells not only in normal brain function...
Attempts to Restore Visual Function After Optic Nerve Damage in Adult Mammals
Tomomitsu Miyoshi, Takuji Kurimoto and Yutaka Fukuda
Retinal ganglion cells (RGCs) and their axons, i.e., optic nerve (ON) fibers, provide a good experimental model for research on damaged CNS neurons and their functional recovery. After the ON transection most RGCs undergo retrograde and anterograde degeneration but they can be rescued and rege...
