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Molecular Imprinting of Polymers


Edited By:

Sergey Piletsky
Institute of BioScience and Technology
Cranfield University
Silsoe, Bedfordshire, U.K.

Anthony Turner
Institute of BioScience and Technology
Cranfield University
Silsoe, Bedfordshire, U.K.

ISBN: 978-1-58706-219-3
Published: 2006-05-12

This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19.




One of Nature’s most important talents is evolutionary development of systems capable of molecular recognition: distinguishing one molecule from another. Molecular recognition is the basis for most biological processes, such as ligandreceptor binding, substrate-enzyme reactions and translation and transcription of the genetic code and is therefore of universal interest. Over the past four decades, researchers have been inspired by Nature to produce biomimetic materials with molecular recognition properties, by design rather than by evolution. A particularly exciting area of biomimetics is Molecular Imprinting, which can be defined as process of template-induced formation of specific recognition sites (binding or catalytic) in a material where the template directs the positioning and orientation of the material’s structural components by a self-assembling mechanism. The material itself could be oligomeric (the typical example is DNA replication process), polymeric (organic MIPs and inorganic imprinted silica gels) or 2-dimensional surface assembly (grafted monolayers). Essentially the current progress in the field of molecular imprinting is a result of fundamental achievements made by more than a hundred groups working in the areas of non-covalent and reversible covalent imprinting. The goal of this title is to capture this momentum and publish a new book that will reflect the current situation in this rapidly evolving technology. Very few of the tens of reviews already published on this subject present a critical analysis of the technological aspects of molecular imprinting. Leaders in this field have been approached with requests to provide their views and analyses of specific areas of design, characterization and application of these polymers. The main body of Molecular Imprinting of Polymers starts with chapters covering polymer design, synthesis, and characterization that are prepared by well-recognized experts such as Andrew Mayes and Natalia Perez-Moral, Claudio Baggiani, Naonobu Katada and Miki Niwa and Franz Dickert. The key part of this book, dedicated to MIP technology, is prepared by MIP pioneers and practitioners who are now at the forefront of the practical application of MIPs: Lars Andersson, Mathias Ulbricht, Borje Sellergren, Michael Whitcombe, Alessandra Bossi, Pier Giorgio Righetti and Staffan Nilsson, Chris Allender, David Spivak, and the editors. The last, but by no means least, part of the book is dedicated to often overlooked associated aspects of MIPs such as commercialization strategy and IPR, prepared by Peter Leverkus and Jeffrey McIntyre.


Chapters available from this book


Business Models for the Commercialisation of MIPs

Peter Leverkus

A high priority for today’s researcher is the need to extract commercial value from a new technology – and MIPs (Molecularly Imprinted Polymers) are no exception to the rule. It is essential to understand that a technology is only of value when used in a specific application, in a market segment,...

Molecularly Imprinted Polymers in Drug Screening

Chris Allender

Molecular imprinted polymers (MIPs) are no longer new materials. Three decades have passed since the early Mosbach and Wulff studies1,2 and the technology is rapidly coming of age. However just what lies ahead for molecular imprinting is far from clear. A search of the literature reveals that res...

Solid-Phase Extraction on Molecularly Imprinted Polymers— Requirements, Achievements and Future Work

Lars I. Andersson

Molecular imprint based solid-phase extraction is increasingly being used for selective extraction of biological and environmental samples. Interest in imprinted polymers is derived from the high selectivities and affinities achievable, and the fact that by the imprinting process these properties...

Chemical Vapor Deposition of Silica Overlayer Using an Organic Molecule As Template on Metal Oxide Surface: Application to Molecular Sieving Sensor and Adsorbent

Naonobu Katada and Miki Niwa

Recent progress is reviewed on the studies carried out to design a reaction field on surfaces consisting purely of metal oxides. Chemical vapor deposition (CVD) of silicon alkoxide, using a molecule as a template, formed a silica overlayer on a weakly basic metal oxide surface with molecular siev...

Molecularly Imprinted Membranes

Mathias Ulbricht

This chapter provides an overview of the emerging and promising field of molecularly imprinted membranes (MIM). The focus is on solid membranes and the separation of molecules, predominately in liquid mixtures. In the first part, fundamentals of synthetic membranes and membrane separation technol...

A New Generation of Chemical Sensors Based on MIPs

Sergey Piletsky and Anthony Turner

Molecular imprinting is a generic technology for the introduction of recognition properties into synthetic polymers. Over the last two decades, molecularly imprinted polymers (MIPs) have become a focus of interest for scientists engaged in the development of biological and chemical sensors. This ...

The Re-Birth of Molecular Imprinting on Silica

Naonobu Katada and Miki Niwa

Molecular imprinting was first attempted between the 1930s – 50s on silica surfaces, but later studies were carried out mainly on organic polymers. However, with advances in technology for the inorganic synthesis of siliceous materials, molecular imprinting on silica has, since the late of 1980s,...

MIP Formats for Analytical Applications

Natalia Perez-Moral and Andrew G. Mayes

As MIPS make the gradual transition from the academic research laboratory to application areas, it is essential that the MIP is designed, both chemically and structurally, to optimise its performance in that particular application. The optimisation of the chemical design is discussed elsewhere in...

MIPs in Biotechnology, Perspective and Reality

David A. Spivak

Over the last five decades, molecularly imprinted polymers (MIPs) have been important as both models and analytical tools for biotechnology. More recently, direct applications as drugs, biosensors, or bioassay materials are increasing the utility of MIPs in bio-related fields. This review will di...

Recognition of Enantiomers Using Molecularly Imprinted Polymers

Borje Sellergren

With the increasing structural complexity of new drugs, the importance of enantiomerically pure compounds is growing.1 Resolution of racemates is often the first step in this process. Conventionally, preparative optical resolution is performed by fractional crystallization, microbiological method...

MIP Catalysts—From Theory to Practice

Michael J. Whitcombe

The principles of the design of transition state analogues are discussed, illustrated with examples taken from the literature on catalytic antibodies. In the following discussion a number of imprinted polymer catalyst systems are described, including those catalyzing elimination reactions, hydrol...

A General Survey of Patents in the Field of Molecularly Imprinted Polymers

Jeffrey B. McIntyre1

This chapter presents a nonexhaustive survey of the types of subject matter for which patent protection has been sought in the field of molecularly imprinted polymers. First, a brief discussion of patents and their practical significance to corporations and universities conducting research and de...

Imprinted Polymers in Capillary Electrophoresis and Capillary Electrochromatography

Alessandra Bossi, Pier Giorgio Righetti and Staffan Nilsson

The use of molecularly imprinted polymers (MIPs) as sorbents in capillary electrophoresis (CE) and capillary electrochromatography (CEC) is an attractive way to combine the high selectivity offered by MIPs with the high separation efficiency (106 theoretical plates) and short time of analysis (a ...

Bioimprinting

Claudio Baggiani, Cristina Giovannoli

Besides main stream, molecular imprinting based on man-made synthetic polymers or silica-imprinted materials, proteins too can be considered as building blocks to prepare artificial molecular recognition systems. The technique of bioimprinting is based on reversible changes in the three dimension...

Molecularly Imprinted Polymers for Mass Sensitive Sensors – from Cells to Viruses and Enzymes

Franz L. Dickert, Peter A. Lieberzeit, Oliver Hayden

Artificial recognition layers for bioanalytes (cells, bacteria, viruses, proteins etc.) combine biological selectivity with the long-term stability of tailored polymers. They can be produced by surface imprinting procedures where the analyte-to-be is used as template and pressed into a prepolymer...

A New Generation of Chemical Sensors Based on MIPs

Sergey Piletsky and Anthony Turner

Molecular imprinting is a generic technology for the introduction of recognition prop erties into synthetic polymers. Over the last two decades, molecularly imprinted polymers (MIPs) have become a focus of interest for scientists engaged in the development of biological and chemical sensors. This...

Molecularly Imprinted Membranes

Mathias Ulbricht

This chapter provides an overview of the emerging and promising field of molecularly imprinted membranes (MIM). The focus is on solid membranes and the separation of molecules, predominately in liquid mixtures. In the first part, fundamentals of synthetic membranes and membrane separation technol...


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