Cardiac Mechanotransduction
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Edited By:Matti WeckstromUniversity of Oulu Oulu, Findland Pasi Tavi University of Oulu Oulu, Findland ISBN: 978-0-387-48867-7 Published: 2006-12-11 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
This book takes a multidisciplinary approach to the topic. The chapters depict the many faces of mechanotransduction, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.
Chapters available from this book
Mechanotransduction of the Endocrine Heart Paracrine and Intracellular Regulation of B-Type Natriuretic Peptide Synthesis
Sampsa Pikkarainen, Heikki Tokola and Heikki Ruskoaho
Cardiac overload initiates a process, which aims to maintain and adapt cardiovascular system to altered hemodynamics. In adults, myocardial mass increases mainly due to enlargement of individual myocytes (for reviews, see refs. 1,2). Cardiac pressure overload in conditions such as aortic steno...
Intracellular Signaling Through Protein Kinases in Cardiac Mechanotransduction
Peter H. Sugden
There is good evidence that stress-induced deformation of the cardiac myocyte can activate intracellular signaling pathways, though how this is brought about is still partly a mystery, some clues being provided by the present volume of reviews. The activation of these signaling pathways is thought t...
Mechanoelectric Transduction/Feedback: Physiology and Pathophysiology
Max J. Lab
Cardiac “mechanotransduction” involves various physiological and biophysical phenomena in which mechanical energy is transduced to changes in function of cardiac myocytes and of the whole heart. In this chapter different manifestations of mechanotransduction are reviewed, with special emphasis on th...
The Role of Adrenoceptors in Mechanotransduction
Klaus-Dieter Schlüter,* Hans Michael Piper and Sibylle Wenzel
Adrenoceptors are a large family of seven membrane spanning G-protein coupled receptors involved in many regulatory processes of the heart. Under conditions of mechanical load to heart, i.e., pressure overload, an activation of the sympathetic nerve system leads directly to stimulation of receptors ...
Second Messenger Systems Involved in Heart Mechanotransduction
Hiroshi Hasegawa, Hiroyuki Takano, Yunzeng Zou, Hiroshi Akazawa and Issei Komuro
Mechanical stress can be considered one of the major stimuli that evoke hypertrophic responses including reprogramming of gene expression in cardiac myocytes. Therefore, it is important to understand how mechanical loading is sensed by cardiomyocytes and converted into intracellular biomechanical si...
Cardiac Remodeling and Heart Failure
Jeffrey H. Omens*, Andrew D. McCulloch and Ilka Lorenzen-Schmidt
Mechanotransduction is the process by which the cells of the heart convert mechanical signals to chemical signals responsible for cellular adaptation and remodeling. When this system cannot meet the demands of increased loading conditions, the cellular response will not be adequate, and eventuall...
The Role of the Sarcomere and Cytoskeleton in Cardiac Mechanotransduction
Sarah C. Calaghan and Ed White
The basic contractile unit of the cardiac myocyte is the sarcomere. Force develops as a result of the interaction of myosin heads with the actin thin filament. Actin filaments are directly connected to the Z line of the sarcomere, whereas myosin filaments are secured via the giant elastic protein...
Origin of Mechanotransduction: Stretch-Activated Ion Channels
Clive M. Baumgarten
Stretch-activated ion channels (SAC) serve as cardiac mechanotransducers. Mechanical stretch of intact tissue, isolated myocytes, or membrane patches rapidly elicits the open ing of poorly selective cation, K+, and Cl- SAC. Several voltage- and ligand-gated channels also are mechanosensitive. SAC...
The Mechanosensory Heart: A Multidisciplinary Approach
Matti Weckström and Pasi Tavi
The cardiac muscle has an intrinsic ability to sense its filling state and react to its changes, independently of cardiac innervation that may partially serve the same functions. This ability, interesting by itself, has also a medical significance because it is associated with disturbances tha...
