I Domains in Integrins
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Edited By:Donald GullbergUniversity of Uppsala ISBN: 978-0-306-47836-9 Published: 2003-07-14 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Structure and Activation of b2 - Integrins
Carl G. Gahmberg and Susanna Fagerholm
Cellular adhesion is essential for several leukocyte functions. A number of adhesion molecules are involved in various adhesive events, but perhaps the most important are the leukocyte specific b2-integrins (CD11/CD18). Recent work has explored integrin structu...
Integrins in Immune and Inflammatory Disease
Antonin R. de Fougerolles
The adhesive interactions of cells with other cells and with extracellular matrix have a central role in regulating immune and inflammatory responses. Integrins are capable of acting at different points along the inflammatory cascade. They are important in initiation of immune responses,...
Collagen-Binding Integrins and Disease
Beate Eckes, Bernhard Nieswandt and Thomas Krieg
Among the b1 family of integrin receptors there are 4 receptors that mediate bind ing to different collagens. These are a1a, a2b, a
Cellular Signaling by Collagen-Binding Integrins
Jyrki Heino
Collagens are structural proteins of extracellular matrix that typically have triple helical domains of variable length.1 Collagens form, for example, the large fibers of connec tive tissues and networks in basement membranes, while some collagens are transmembrane proteins. Metazoans fr...
Integrin Recognition Motifs in Collagens
Richard W. Farndale
The vertebrate integrins are a family of twenty four heterodimeric transmembrane sig nalling and adhesion molecules, found in very many cells types where their expression and affinity is carefully regulated, reviewed in Chapter 1 and.1,2 Integrins mediate either cell–cell interactions,...
Structural Aspects of Integrins
Robert C. Liddington
Structural studies on integrins have recently made great strides. In the past three years, crystal structures of the complete extracellular fragment of one integrin, aVb3,1 two a-I domains in complex with li...
Integrin aEb7: Molecular Features and Functional Significance in the Immune System
Peter J. Kilshaw and Jonathan M.G. Higgins
Abstract Alpha E beta 7 is an a-I domain-containing
integrin that is expressed mainly on T cells, dendritic cells and mast cells
in mucosal tissues. Expression depends largely or solely on TGF-b.
The best characterized ligand for
Structure and Function of a11b1
Donald Gullberg, Svetlana N. Popova and Carl-Fredrik Tiger
The a11 integrin chain constitutes the latest addition to the integrin family. a11b1 was originally identified on cultured human muscle cells, but recent studies have shown that it is not expressed on muscle...
Structure Distribution and Function of a10b1
Evy Lundgren-Åkerlund and Max Schneller
Introduction The integrin a10b1 was originally identified as a collagen type II binding integrin on chondrocytes.1 The bovine integrin subunit a10 was isolated from chondrocyte lysates by affinity chromatogr...
Function of a2b1 Integrin
Mary M. Zutter and Samuel A. Santoro
The a2b1 integrin serves as an extracellular matrix receptor for collagen and /or laminin, as well as several other nonmatrix ligands.1-3 Interactions between the a2b1 integrin and...
Integrin a1b1
Humphrey Gardner
Introduction The integrin a1 subunit was first discovered by Hemler et al as the a component of the Very Late Antigen I (VLA1) expressed on a subset of T cells in the joints of patients with rheumatoid arthritis,1 as well as in a s...
Evolution of Integrin I-Domains
Mark S. Johnson and Danny Tuckwell
In humans, I domains are ~200 residue long sequences that are “inserted” into the N-terminal domain of all 8 integrin a subunits and 9 of the 18 integrin b subunits. The integrin I-domains are related to the von Willebrand factor ...
