Muscle Development in Drosophila
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Edited By:Helen SinkNew York University ISBN: 978-0-387-30053-5 Published: 2006-01-25 |
Muscles have multiple roles in organisms. These roles range from facilitating conscious and unconscious movement, to maintaining posture, stabilizing joints, generating body heat, and moving substances within the body. To successfully carry out these functions, each muscle must develop as the right muscle type in the right location, achieve and maintain appropriate size, possess a correctly ordered contractile apparatus, and be capable of responding to contraction?inducing stimuli. A fundamental question is: How does a muscle develop so that it possesses the properties required for correct functioning? This book reviews how the fruit fly, Drosophila melanogaster, is being used to address this question. The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. Muscle Development in Drosophilia will appeal to those studying muscle development and muscle biology in any organism.
Chapters available from this book
The Muscle Pattern of Drosophila
Volker Hartenstein
The musculature of insects is composed of an external, multilayered array of body wall muscles (somatic musculature), an internal layer of visceral muscles that surround the digestive tract and gonads, and specialized myo-epithelial tubes forming the vascular system. All three types of muscle are re...
An Introduction to Muscle Development in Drosophila
Helen Sink
Muscles have multiple roles in organisms. These roles range from facilitating conscious and unconscious movement, to maintaining posture, stabilizing joints, generating body heat, and moving substances within the body. To successfully carry out these functions, each muscle must develop as the rig...
Comparison of Muscle Development in Drosophila and Vertebrates
Michael V. Taylor
There are many fundamental similarities in the biology of Drosophila and vertebrates, and Drosophila has become a prominent model organism for studies of animal develop ment. Here the development of the different vertebrate muscle types (skeletal, cardiac and smooth) is compared with their anatom...
Molecular Basis of Muscle Structure
Jim O. Vigoreaux
The flight muscle myofibril is a precisely assembled cytoskeletal network of contractile proteins that produces high power to sustain flight. This chapter will focus on myofibrillar assembly during development of the indirect flight muscles. Studies in Drosophila melanogaster have combined geneti...
Metamorphosis and the Formation of the Adult Musculature
Devkanya Dutta and K. VijayRaghavan
The somatic musculature of the adult fly comprises of muscles that are morphologically and functionally very distinct from each other. How are these diverse muscle types generated during pupal development? This chapter summarizes the insights that have been gained into the genetic and molecular m...
Development of the Larval Somatic Musculature
Ana Carmena and Mary Baylies
The larval somatic musculature of Drosophila is arranged in a highly stereotyped pattern of 30 muscle fibers per hemisegment. Each muscle possesses a distinctive set of properties: size, shape, orientation, attachments to the epidermis and specific innervation. These qualities make each myofiber ...
Muscle Attachment Sites—Where Migrating Muscles Meet Their Match
Talila Volk
The precise match between somatic muscles and their epidermal muscle attachment cells is achieved through a continuous dialogue between these two cell types. Initially, an intricate pattern of tendon precursors is produced within the epidermis. The tendon precursor cells guide the somatic myotube...
Muscle Morphogenesis: The Process of Embryonic Myoblast Fusion
Susan M. Abmayr and Kiranmai S. Kocherlakota
One important aspect of myogenic differentiation in Drosophila melanogaster, as in many other organisms, is the generation of multinucleate muscle fibers through the fusion of myoblasts. This process cannot be initiated until the myoblasts have differentiated to a point at which they become compe...
Neuromuscular Development: Connectivity and Plasticity
Louise Nicholson and Haig Keshishian
The Drosophila neuromuscular junction provides an excellent model system in which to study synaptic development. Axon outgrowth, target selection, and synaptogenesis have been extremely well characterized and occur with remarkable precision. Coupled with the powerful molecular genetic approaches ...
Development of the Somatic Gonad and Fat Bodies
Mark Van Doren
The development of the Drosophila fat body and gonads represent excellent models for studying cell type specification, patterning and morphogenesis during organ formation. Moreover, these organs are critical for the proper homeostasis of one generation of the species, while ensuring the productio...
Development of the Larval Visceral Musculature
Hsiu-Hsiang Lee, Stephane Zaffran and Manfred Frasch
The visceral mesoderm of Drosophila forms the thin layers of muscle fibers surrounding the digestive tract. Both during their development and after differentiation, these muscle tissues have crucial roles in the morphogenesis and functioning of the gut tube. The visceral muscles of the foregut, m...
Whole Genome Approaches to Studying Drosophila Muscle Development
Eileen E.M. Furlong
With the development of microarray technology, and other whole-genome approaches, it is now possible to systematically screen an entire genome for genes that are differentially expressed during two different stages of development and/or two different types of cells. This can be readily applied to...
Mesoderm Formation in the Drosophila Embryo
Noriko Wakabayashi-Ito, Y. Tony Ip
All muscle cells develop from the mesoderm, which is the middle germ layer in the early embryo. The mesoderm itself derives from the ventral cells of the blastoderm stage embryo. Therefore, the regulatory events controlling dorsal-ventral development in the oocyte and the early embryo are the ear...
