Fibrogenesis: Cellular and Molecular Basis
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Edited By:Mohammed Shawkat RazzaqueHarvard School of Dental Medicine ISBN: 978-0-306-47861-1 Published: 2004-12-24 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Chapters available from this book
Silica-Induced Inflammatory Mediators and Pulmonary Fibrosis
Andrea K. Hubbard, Sarah Mowbray, Michael Thibodeau and Charles Giardina
Silicosis continues to be a lung disease with significant morbidity and mortality. Although silica- induced lung injury and cell activation and/or death has been investigated over the past several years, basic research continues to reveal the cell: cell and cell: mediator interactions critical to...
Reversibility of Liver Fibrosis: Role of Matrix Metalloproteinases
Isao Okazaki, Tetsu Watanabe, Maki Niioka, Yoshihiko Sugioka and Yutaka Inagaki
Reversibility of liver fibrosis has been reported both experimentally and clinically, if the cause of liver damage is removed or adequately treated. We first reported the collagenase activity in the process of experimental liver fibrosis in 1974. The present review discusses the participation of ...
Recent Therapeutic Developments in Hepatic Fibrosis
Ichiro Shimizu
Currently, hepatic fibrogenesis is viewed as a dynamic process strictly related to the extent and duration of liver injury. Activated hepatic stellate cells (HSCs) are identi fied as the major source of extracellular matrix components in the injured liver, and are regarded as a target for antifib...
Cardiac Fibrosis and Aging
Serge Masson, Roberto Latini, Monica Salio and Fabio Fiordaliso
Excessive deposition of extracellular matrix proteins during aging leads to a progressive reduction of myocardial and arterial compliances. The increased cardiovascular stiffness may in turn determine a reduced capacity of the aged heart to respond to stressful situations. Our knowledge on the bi...
Molecular Developments in the Treatment of Renal Fibrosis
Gavin J. Becker and Tim D. Hewitson
Progressive renal disease is associated with the development of fibrosing lesions not only in the glomerulus, but also in the interstitial and vascular compartments of the kidney, in a process that involves the mesenchymally derived, phenotypically similar, mesangial cell, myofibroblast and vascu...
Low-Density Lipoprotein and Glomerulosclerosis
Hyun Soon Lee
Hypercholesterolemia is a common feature of nephrosis or uremia. Dietary hypercholesterolemia aggravates the renal injury in experimental focal segmental glomerulosclerosis (FSGS). Hypercholesterolemia is mainly due to increased level of low-density lipoprotein (LDL). Accumulation of apolipoprote...
Involvement of NF-kB in Renal Inflammation and Sclerosis
Laurent Baud, Bruno Fouqueray, Agnes Bellocq, Jean-Philippe Haymannn and Julie Peltier
Nuclear factor-kB (NF-kB) comprises a family of transcription factors. They are thought to have a central role in the expression of genes involved in cell mobilization, cell proliferation and cell differentiation, and, hence, in inflammation, repair and fibrosis processes. In particular, NF-kB ac...
Oxidative Stress, Lipoproteins and Angiotensin II— The Unholy Triade in the Pathogenesis of Renal Fibrosis
Jan Galle, Thomas Quaschning and Stefan Seibold
Renal fibrosis usually indicates irreversible tissue damage, irrespective of the initial cause. Thus, it is most relevant to understand mechanisms leading to renal fibrosis. Oxidative stress has emerged as an important factor contributing to tissue damage, and oxidative stress is enhanced in a va...
Pathological Significance of Renal Expression of Proinflammatory Molecules
Takashi Wada, Mohammed S. Razzaque, Kouji Matsushima, Takashi Taguchi and Hitoshi Yokoyama
Recent studies of cytokines, chemokines, adhesion molecules and growth factors have enhanced our understanding of molecular mechanisms of leukocyte trafficking and their activation in the inflammatory phase of various renal diseases. Interactions between infiltrated inflammatory cells and residen...
Tissue Scarring Lessons from Wound Healing
Mohammed S. Razzaque, Moussa El-Hallak, Abdallah Azouz and Takashi Taguchi
Tissue scarring due to abnormal matrix remodeling is an important cause of organ fail ure, which is a leading cause of morbidity and mortality. Current studies have focused on determination of the molecular basis of controlled wound healing, and uncontrolled tissue scarring. Scarless repair is a ...
Can Manipulation of Apoptotic Cell Death Benefit Tissue Scarring?
Wesam Ahmed, Mohammed S. Razzaque and Takashi Taguchi
Cell death by apoptosis is an active process of cell removal that is initiated and regulated by activation of specific enzymes and signaling molecules. In contrast to necrotic cell death, apoptotic cell death holds the potential for therapeutic manipulation. Recent studies document important role...
Pulmonary Firbogenesis: The Role of Apoptosis and its Clinical Potentials
Kazuyoshi Kuwano, Naoki Hagimata and Nobuyuki Hara
Pulmonary fibrosis is a common response to various insults or injuries to the lung. Al though there are various initiating factors or causes, the terminal stages are characterized by proliferation and progressive accumulation of connective tissue replacing normal functional parenchyma. Conventi...
Molecular and Cellular Aspect of Liver Fibrosis
Norifumi Kawada
Hepatic stellate cells play essential roles in the pathogenesis of liver fibrosis. Transformation of stellate cells from the vitamin A-storing pheno type to the “myofibroblastic” one closely correlates to hepatic fibrogenesis during chronic liver diseases. Understanding the molecular mechanisms...
