Islet Cell Growth Factors
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Edited By:Rohit N. KulkarniJoslin Diabetes Center and Harvard Medical School ISBN: TBA Published: 2008-12-01 |
Chapters available from this book
Role of Parathyroid Hormone-Related Protein and Lactogens in the Pancreatic Beta Cell
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With the current rate of escalation in diabetes worldwide the need to treat and cure the disease is imperative from the standpoint of avoiding both a health and a related economic crisis in the future. In the past decade there has been an impetus in the search for the cause(s), the treatment, ...
Role of FoxO Proteins in Pancreatic b Cells
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Forkhead transcription factors of the FoxO family have important roles in cellular proliferation, apoptosis, differentiation and stress resistance. FoxO proteins also play important roles in metabolism of complex organisms. FoxO1 regulates glucose and lipid metabolism in liver, as well as pr...
b Cell Proliferation as the Major Determinant of Pancreatic b Cell Mass
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A fundamental problem in pancreas biology concerns the cellular origins of adult pancreatic b cells. Identifying the cells that give rise to new b cells will have important implications for the design of future regenerative therapies for diabetes. Numerous studies have suggested that b cells...
Hepatocyte Growth Factor (HGF) and the Pancreatic Beta Cell
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Studies performed in vivo using genetically modified mouse models have shown that growth factors are regulators of beta cell growth and differentiation. Hepatocyte growth factor (HGF), initially identified as a circulating factor implicated in hepatic regeneration, displays pleiotropic actions...
Akt and Pancreatic b-Cell Growth and Function
Ernesto Bernal-Mizrachi
The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence u...
Cell Cycle Regulation and Beta Cells
Senta Georgia and Anil Bhushan
Cells regulate proliferation by entering and progressing through the cell cycle. Conversely, cell growth is arrested by exiting the cell cycle. A balance of extrinsic and intrinsic signals normally mediates progression through or exit from the cell cycle.1 When mitotic signals are received b...
Role of Pdx-1 in β-Cell Growth
J. Nina Ham and Doris A. Stoffers
PDX-1 is a homeodomain transcription factor that acts as a key regulator of pancreas development, pancreatic b-cell differentiation, and b-cell function. It is one of the earliest markers of pancreatic morphogenesis, and its expression is maintained throughout the life of the pancreatic b-cell, indi...
