Rb and Tumorigenesis
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Edited By:Maurizio FanciulliRegina Elena Cancer Institute Rome, Italy ISBN: 978-0-387-32173-8 Published: 2006-03-10 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
Rb and Tumorigenesis examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle.
Chapters available from this book
Rb and Cellular Differentiation
Lucia Latella and Pier Lorenzo Puri*
The pivotal role of the Retinoblastoma gene product p110 (pRb) in cellular differentiation has been postulated since the identification of pRb as a target of oncogenic events.1-3 The demonstration of the essential role of pRb during terminal differentiation of many tissues appeared evident along ...
Regulation of Rb Function by Noncyclin Dependent Kinases
Jaya Padmanabhan and Srikumar P. Chellappan
Inactivation of the retinoblastoma tumor suppressor protein, Rb, is necessary for the normal progression of the mammalian cell cycle.1 Studies over the past fifteen years have shown that Rb protein is inactivated by kinases associated with cyclins, especially cyclins D and E, which facilitate the...
Regulation of E2F-Responsive Genes through Histone Modifications
Estelle Nicolas, Laetitia Daury and Didier Trouche
The retinoblastoma protein Rb, when targeted to E2F-responsive promoters through a direct interaction with E2F proteins, actively represses transcription. This property is shared by the two Rb-related proteins, p107 and p130. Active transcriptional repression by Rb is important for the proper con...
Regulation of DNA Replication by the Retinoblastoma Tumor Suppressor Protein
Erik S. Knudsen and Steven P. Angus
The retinoblastoma gene product (RB) plays a critical role in the inhibition of cancer. This prototypical tumor suppressor was identified based on bi-alleleic inactiviation in the pediatric tumor retinoblastoma. Subsequently, it has become clear that multiple pathways lead to the functional inact...
pRb in the Differentiation of Normal and Neoplastic Cells
Deborah Pajalunga, Grazia Camarda and Marco Crescenzi
This chapter deals with the role played by the retinoblastoma protein (pRb) in a variety of differentiation processes. After broadly reviewing the current knowledge on this issue, it points at two common themes. The first is the exclusive involvement of pRb in the final maturation stages of each ...
RB as Positive Transcriptional Regulator During Epithelial Differentiation
Chantal E. Cremisi and Linda L. Pritchard
RB plays an essential role in epithelial cell differentiation and viability, these two properties being totally linked and independent of p53. To exert these functions, RB acts as a positive transcriptional coregulator, being recruited to the native gene promoters by sequence-specific transcripti...
Diverse Regulatory Functions of the E2F Family of Transcription Factors
Fred Dick and Nick Dyson
E2F activity is largely controlled by cell cycle dependent phosphorylation of the Retino blastoma family of proteins (eg. pRB). Regulation of E2F transcription factors by RB-family proteins is crucial to the regulation of cell cycle entry. In addition to masking E2F activation of transcription, p...
Emerging Roles for the Retinoblastoma Gene Family
Jacqueline L. Vanderluit, Kerry L. Ferguson and Ruth S. Slack
Research on the retinoblastoma protein has grown from studying its role as a tumour suppressor in cancer to identifying it as a key regulator of the cell cycle G1/S check point and today to exploring its function in numerous cellular processes. The recent development of conditional knockout mice ...
New Insights Into Transcriptional Regulation by RB: One Size No Longer Fits All
Peggy J. Farnham
The retinoblastoma (Rb) protein is a key regulator of cell proliferation, differentiation, and tumorigenesis. Initial studies of Rb revealed that it binds to, and decreases the activity of, the E2F family of transcription factors. Over the last decade, the mechanisms by which Rb regulates E2F act...
