Lipid A in Cancer Therapy
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Edited By:Jean-François JeanninUniversité Bourgogne ISBN: TBA Published: 2008-12-01 |
Chapters available from this book
Conformation and Supramolecular Structure of Lipid A
Klaus Brandenburg and Ulrich Seydel
In recent years, lipid A as ‘endotoxic principle’ of bacterial lipopolysaccharide (LPS) and derivatives thereof have become increasingly important in the field of biomedical application such as for vaccination or as therapeutical, e.g., anti‑tumor agent. For an understanding of these biologica...
Interactions between Lipid A and Serum Proteins
Jörg Andrä, Thomas Gutsmann, Mareike Müller and Andra B. Schromm
Entry of endotoxin (lipopolysaccharide (LPS) or lipid A) into the blood stream is causative for the emergence of sepsis and septic shock with all its pathophysiological consequences.1 Serum contains a whole variety of proteins that interact with endotoxin. As large as the number of different protein...
The Lipid A Receptor
Kiyoshi Takeda
The lipid A receptor consists of several subunits. Lipopolysaccharide binding protein (LBP) is a serum protein facilitating association of lipid A with CD14. The Lipid A-LBP-CD14 complex is further delivered to Toll-like receptor 4 (TLR4), which is essential for lipid A-mediated cellular activation....
Lipid A in Cancer Therapies Preclinical Results
Daniéle Reisser
Studies in animal models showed that the antitumoral effect of LPS and of their biologically active moiety, lipid A, is indirect and relies on the induction of an immune response both innate and specific, leading to cytokine production. They also affect tumor development by inhibiting tumor blood fl...
Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti‑Cancer Vaccines: Clinical Results
Christopher W. Cluff
A variety of vaccines designed for cancer immunotherapy have been tested in clinical trials for more than two decades. Investigators realized early on that addition of adjuvants to cancer vaccines would be required to overcome the poor immune responses that are generally elicited to antigens contain...
Antitumoral Effects of Lipids A, Clinical Studies
Marc Bardou and Daniéle Reisser
Cancer remains the second leading cause of death, after cardiovascular diseases, in industrialized countries. The first goal to achieve is to prevent cancer occurrence or to diagnose it at an early and curable stage. Some screening strategies have been developed, with controversies across countries,...
Lipid A-Mediated Tolerance and Cancer Therapy
Cheryl E. Rockwell, David. C. Morrison and Nilofer Qureshi
The occurrence of tolerance or host unresponsiveness in animals and humans administered multiple doses of microbe or microbial products has long been recognized by scientists and physicians with published reports appearing in professional journals dating back to the 19th century.1 Many of the very e...
Lipid A Receptor TLR4‑Mediated Signaling Pathways
Masahiro Yamamoto and Shizuo Akira
Lipid A is a strong activator of monocytes to release immune stimulators such as proinflammatory cytokines. Overproduction of inflammatory cytokines such as TNF and IL‑6 is known to cause septic shock that frequently leads to multiple organ failure and finally to death. In recent years, Lipid ...
Structure and Synthesis of Lipid A
Shoichi Kusumoto, Masahito Hashimoto and Kazuyoshi Kawahara
Lipid A is the lipophilic partial structure of bacterial lipopolysaccharide (LPS), which is a characteristic and essential component of the cell surface architecture of Gram negative bacteria. LPS constitutes the outer leaflet of the lipid bilayer of outer membrane which covers the outermost surface...
