Bio-Applications of Nanoparticles
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Edited By:Warren C.W. ChanIBBME and CCBR University of Toronto Toronto, Ontario, Canada ISBN: 978-0-387-76712-3 Published: 2007-11-16 This book may be purchased as an eBook (pdf) for $99, or individual chapters (pdf) may be purchased from the list below for $19. |
In this edited book, we highlight the central players in the Bionanotechnology field, which are the nanostructures and biomolecules. The book starts by describing how nanostructures are synthesized and by describing the wide variety of nanostructures available for biological research and applications. Also shown are the techniques used to synthesize a wide variety of biological molecules. Next, there is a focus on the assembly of nanostructures with biological molecules, which could lead to the design of multi-functional nanosystems. In the following chapters, examples of the unique properties of nanostructures are provided along with the current applications of these nanostructures in biology and medicine. Some applications include the use of gold nanoparticles in diagnostic applications, quantum dots and silica nanoparticles for imaging, and liposomes for drug delivery. In the final chapters of the book, the toxicity of nanostructures are described. This book provides broad examples of current developments in Bionanotechnology research and would be an excellent introduction to the field.
Chapters available from this book
Carbon Nanostructures as a New High-Performance Platform for MR Molecular Imaging
Keith B. Hartman and Lon J. Wilson
Over the last several years, great interest has developed in the potential use of carbon nanostructures (C60 fullerenes and nanotubes) in medicine. In some cases, medical agents derived from these materials have demonstrated greater efficacy than existing clinical agents in many imaging and therapeu...
Quantum Dots for Cancer Molecular Imaging
Xiaohu Gao and Shivang R. Dave
Quantum dots (QDs), tiny light-emitting particles on the nanometer scale, are mproved signal brightness, resistance against photobleaching, and simultaneous excitation of multiple fluorescence colors. These properties are most promising for improving the sensitivity of molecular imaging and quantita...
Current Approaches for Engineering Proteins with Diverse Biological Properties
Isaac T.S. Li, Elizabeth Pham and Kevin Truong
In the past two decades, protein engineering has advanced significantly with the emergence of new chemical and genetic approaches. Modification and recombination of existing proteins not only produced novel enzymes used commercially and in research laboratories, but furthermore, they revealed the me...
Fluorescent Nanoparticle for Bacteria and DNA Detection
Wenjun Zhao, Lin Wang and Weihong Tan
Using bioconjugated dye-doped silica nanoparticles (NPs), we have developed a bioassay for the accurate determination of a single bacterial cell within 20 minutes without any signal amplification or sample enrichment. The antibody-conjugated NPs can specifically and quantitatively detect bacteria, s...
Liposomes in Biology and Medicine
Reto A. Schwendener
Drug delivery systems (DDS) have become important tools for the specific delivery of a large number of drug molecules. Since their discovery in the 1960s liposomes were recognized as models to study biological membranes and as versatile DDS of both hydrophilic and lipophilic molecules. Liposomes—nan...
Patterning Metallic Nanoparticles by DNA Scaffolds
Rahul Chhabra, Jaswinder Sharma, Yan Liu and Hao Yan
In order to miniaturize nanoelectronic circuitry and architectures, organizing the nanoelectronic components in deliberately designed complex patterns is desired. Bio-mimetic self-assembly is a possible approach to achieve this goal. Bio-macromolecules can serve as scaffolds to template the nanoelec...
Magnetic Nanoparticle Assisted Molecular MR Imaging
Young-wook Jun, Jung-tak Jang and Jinwoo Cheon
Magnetic nanoparticles exhibit unique nanoscale properties of superparamagnetism and have the potential to be utilized as excellent probes for magnetic resonance imaging (MRI). Especially, clinically benign iron oxide nanoparticles provide good MR probing capability and some of them are currently av...
Dendrimer 101
Lajos P. Balogh
In this chapter dendrimer basics are reviewed. It is impossible to describe, refer to or even list the related literature (our “dendrimer” database consists of over 7,000 papers and patents), thus selection of references has been made based on personal preference, often choosing clarity over details...
Synthetic Strategies to Size and Shape Controlled Nanocrystals and Nanocrystal Heterostructures
P. Davide Cozzoli and Liberato Manna
The recognition of the strongly dimensionality-dependent physical-chemical properties of inorganic matter at the nanoscale has stimulated efforts toward the fabrication of nanostructured materials in a systematic and controlled manner. Surfactant-assisted chemical approaches have now advanced to the...
Quantum Dots and Other Fluorescent Nanoparticles: Quo Vadis in the Cell?
Dusica Maysinger and Jasmina Lovric
An exponentially growing number of nanotechnology-based products are providing new platforms for research in different scientific disciplines (e.g., life sciences and medicine). Biocompatible nanoparticles are expected to significantly impact the development of new approaches in medical diagnoses an...
Toxicity Studies of Fullerenes and Derivatives
Jelena Kolosnjaj, Henri Szwarc and Fathi Moussa
Due to their unique properties, fullerenes, a model of carbon-based nanoparticles, have attracted considerable interest in many fields of research including material science and biomedical applications. The potential and the growing use of fullerenes and their mass production have raised several que...
Toxicity Studies of Carbon Nanotubes
Jelena Kolosnjaj, Henri Szwarc and Fathi Moussa
As for fullerenes, the potential and the growing use of CNT and their mass production have raised several questions about their safety and environmental impact. Research on the toxicity of carbon nanotubes has just begun and the data are still fragmentary and subject to criticisms. Preliminary resul...
Multi-Functional Gold Nanoparticles for Drug Delivery
Gang Han, Partha Ghosh and Vincent M. Rotello
Multi-functional gold nanoparticles have been demonstrated to be highly stable and versatile scaffolds for drug delivery due to their unique size, coupled with their chemical and physical properties. The ability to tune the surface of the particle provides access to cell-specific targeting and contr...
Past, Present, and Future of Gold Nanoparticles
Travis Jennings and Geoffrey Strouse
Colloidal gold nanoparticles have been around for centuries. Historically, the use of gold nanoparticles has been predominantly found in the work of artists and craftsman because of their vivid visible colors. However, through research, the size, shape, surface chemistry, and optical properties of g...
