Ryutaro Utsumi
Department of Bioscience, Graduate School of Agriculture, Kinki University

About this Book

This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these developments have been put together in this book, Bacterial Signal Transduction: Networks and Drug Targets. The aim of this book is to provide an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs.

Table of Contents

1. Introduction to Bacterial Signal Transduction Networks
Yoko Eguchi and Ryutaro Utsumi

2. The PhoQ/PhoP Regulatory Network of Salmonella enterica
Akinori Kato and Eduardo A. Groisman

3. Structural Basis of the Signal Transduction in the Two Component System
Seiji Yamada and Yoshitsugu Shiro

4. The Two-Component Network and the General Stress Sigma Factor RpoS (σ^S)
in Escherichia coli
Regine Hengge

5. Small RNAs Controlled by Two-Component Systems
Claudio Valverde and Dieter Haas

6. Two-Component Signaling and Gram Negative Envelope Stress Response Systems
Dawn M. MacRitchie, Daelynn R. Buelow, Nancy L. Price and Tracy L. Raivio

7. Dual Regulation with Ser/Thr Kinase Cascade and a His/Asp TCS
in Myxococcus xanthus
Sumiko Inouye and Hirofumi Nariya

8. Two-Component Signaling Systems and Cell Cycle Control
in Caulobacter crescentus
Erin B. Purcell, Cara C. Boutte and Sean Crosson

9. RegB/RegA, A Global Redox Responding Two Component System
Jiang Wu and Carl E. Bauer

10. The BvgS/BvgA Phosphorelay System of Pathogenic Bordetellae:
Structure, Function and Evolution
Dagmar Beier and Roy Gross

11. Capturing the VirA/VirG TCS of Agrobacterium tumefaciens
Yi-Han Lin, Rong Gao, Andrew N. Binns and David G. Lynn

12. Q uorum Sensing and Biofilm Formation by Streptococcus mutans
Dilani Senadheera and Dennis G. Cvitkovitch

13. The Roles of Two Component Systems in Virulence of Pathogenic
Escherichia coli and Shigella spp.
Toru Tobe

14. Vancomycin Resistance VanS/VanR Two Component Systems
Hee-Jeon Hong, Matthew I. Hutchings and Mark J. Buttner

15. Tearing Down the Wall: Peptidoglycan Metabolism and the WalK/WalR
(YYCG/YYCF) Essential Two Component System
Sarah Dubrac and Tarek Msadek

16. Inhibitors Targeting Two Component Signal Transduction
Takafumi Watanabe, Ario Okada, Yasuhiro Gotoh and Ryutaro Utsumi