Chapter category: Adhesion Molecules
Evolution of Integrin I-Domains
I Domains in Integrins
Edited by: Donald GullbergISBN: 0-306-47836-6
» Get more information about this book at landesbioscience.com «
Chapter authors:
Mark S. Johnson and Danny Tuckwell
In humans, I domains are ~200 residue long sequences that are “inserted” into the N-terminal domain of all 8 integrin a subunits and 9 of the 18 integrin b subunits. The integrin I-domains are related to the von Willebrand factor A domains (VWFA), found in a wide range of proteins in both prokaryotes and eukaryotes. Analysis of the I-domains and VWFA domains from a range of metazoans shows that the full complement of a and b I-domains found in humans are present in bony fish. Homologues of the b I domains are not present in protostomes although homologues of VWFA domains, b subunits without I domains, and a subunits with I domains are present. Some of the protostome VWFA domain proteins are involved in extracellular matrix function, showing interesting functional parallels with vertebrate I-domain integrins. It seems likely that the present day set of integrin I-domains in vertebrates is a product of the requirements dictated by the large changes in body plan and the evolving immune system initiated in the early deuterostomes and chordates some 600 million years ago.
Additional chapters from this book:
Structure and Activation of b2 - Integrins
Carl G. Gahmberg and Susanna Fagerholm
Cellular adhesion is essential for several leukocyte functions. A number of adhesion molecules are involved in various adhesive events, but perhaps the most important are the leukocyte specifi...
Integrins in Immune and Inflammatory Disease
Antonin R. de Fougerolles
The adhesive interactions of cells with other cells and with extracellular matrix have a central role in regulating immune and inflammatory responses. Integrins are capable of acting at differ...
Collagen-Binding Integrins and Disease
Beate Eckes, Bernhard Nieswandt and Thomas Krieg
Among the b1 family of integrin receptors there are 4 receptors that mediate bind ing to different collagens. These are a1
Cellular Signaling by Collagen-Binding Integrins
Jyrki Heino
Collagens are structural proteins of extracellular matrix that typically have triple helical domains of variable length.1 Collagens form, for example, the large fibers of connec tive tissues a...
Integrin Recognition Motifs in Collagens
Richard W. Farndale
The vertebrate integrins are a family of twenty four heterodimeric transmembrane sig nalling and adhesion molecules, found in very many cells types where their expression and affinity is caref...
Structural Aspects of Integrins
Robert C. Liddington
Structural studies on integrins have recently made great strides. In the past three years, crystal structures of the complete extracellular fragment of one integrin, a
Integrin aEb7: Molecular Features and Functional Significance in the Immune System
Peter J. Kilshaw and Jonathan M.G. Higgins
Abstract Alpha E beta 7 is an a-I domain-containing integrin that is expressed mainly on T cells, dendritic cells and mast cells in mucosal tissues. Expression depen...
Structure and Function of a11b1
Donald Gullberg, Svetlana N. Popova and Carl-Fredrik Tiger
The a11 integrin chain constitutes the latest addition to the integrin family. a11b1 was originally identified ...
Structure Distribution and Function of a10b1
Evy Lundgren-Åkerlund and Max Schneller
Introduction The integrin a10b1 was originally identified as a collagen type II binding integrin on chondrocytes.1 The bovine integrin sub...
Function of a2b1 Integrin
Mary M. Zutter and Samuel A. Santoro
The a2b1 integrin serves as an extracellular matrix receptor for collagen and /or laminin, as well as several other nonmatrix ligands.1-3 ...
Integrin a1b1
Humphrey Gardner
Introduction The integrin a1 subunit was first discovered by Hemler et al as the a component of the Very Late Antigen I (VLA1) expresse...
Evolution of Integrin I-Domains
Mark S. Johnson and Danny Tuckwell
In humans, I domains are ~200 residue long sequences that are “inserted” into the N-terminal domain of all 8 integrin a subunits and 9 of the 18 integrin
