Chapter category: Adhesion Molecules

Function of a2b1 Integrin

This chapter appears in the following book:

I Domains in Integrins

Edited by: Donald Gullberg
ISBN: 0-306-47836-6
» Get more information about this book at landesbioscience.com «

Chapter authors:
Mary M. Zutter and Samuel A. Santoro

[+] view image

The a2b1 integrin serves as an extracellular matrix receptor for collagen and /or laminin, as well as several other nonmatrix ligands.1-3 Interactions between the a2b1 integrin and the extracellular matrix have been implicated in a number of biologic and pathobiologic processes.4 The important role that the a2b1 integrin serves as a collagen receptor on platelets for platelet function and hemostasis is well established.4-7 In some cell types such as endothelial cells and epithelial cells, a more activated form of the receptor may serve as both a collagen and laminin receptor.3,8 Extensive in vitro studies on pulmonary, gastrointestinal and breast epithelia suggest that signals downstream of a2b1 integrin ligation contribute to branching morphogenesis.9-12 Experiments using explant cultures and 3-dimensional collagen gels have implicated the a2b1 integrin in keratinocyte migration and fibroblast contraction during wound healing.13-15 The role of the a2a1 integrin in these multiple complex biologic processes will be discussed in this chapter. system. collagen subtypes.

» Access chapter for $19

Additional chapters from this book:

Structure and Activation of b₂ - Integrins

Carl G. Gahmberg and Susanna Fagerholm

Cellular adhesion is essential for several leukocyte functions. A number of adhesion molecules are involved in various adhesive events, but perhaps the most important are the leukocyte specifi...

Integrins in Immune and Inflammatory Disease

Antonin R. de Fougerolles

The adhesive interactions of cells with other cells and with extracellular matrix have a central role in regulating immune and inflammatory responses. Integrins are capable of acting at differ...

Collagen-Binding Integrins and Disease

Beate Eckes, Bernhard Nieswandt and Thomas Krieg

Among the b1 family of integrin receptors there are 4 receptors that mediate bind ing to different collagens. These are a1

Cellular Signaling by Collagen-Binding Integrins

Jyrki Heino

Collagens are structural proteins of extracellular matrix that typically have triple helical domains of variable length.1 Collagens form, for example, the large fibers of connec tive tissues a...

Integrin Recognition Motifs in Collagens

Richard W. Farndale

The vertebrate integrins are a family of twenty four heterodimeric transmembrane sig nalling and adhesion molecules, found in very many cells types where their expression and affinity is caref...

Structural Aspects of Integrins

Robert C. Liddington

Structural studies on integrins have recently made great strides. In the past three years, crystal structures of the complete extracellular fragment of one integrin, a

Integrin aEb7: Molecular Features and Functional Significance in the Immune System

Peter J. Kilshaw and Jonathan M.G. Higgins

Abstract Alpha E beta 7 is an a-I domain-containing integrin that is expressed mainly on T cells, dendritic cells and mast cells in mucosal tissues. Expression depen...

Structure and Function of a11b1

Donald Gullberg, Svetlana N. Popova and Carl-Fredrik Tiger

The a11 integrin chain constitutes the latest addition to the integrin family. a11b1 was originally identified ...

Structure Distribution and Function of a10b1

Evy Lundgren-Åkerlund and Max Schneller

Introduction The integrin a10b1 was originally identified as a collagen type II binding integrin on chondrocytes.1 The bovine integrin sub...

Function of a2b1 Integrin

Mary M. Zutter and Samuel A. Santoro

The a2b1 integrin serves as an extracellular matrix receptor for collagen and /or laminin, as well as several other nonmatrix ligands.1-3 ...

Integrin a1b1

Humphrey Gardner

Introduction The integrin a1 subunit was first discovered by Hemler et al as the a component of the Very Late Antigen I (VLA1) expresse...

Evolution of Integrin I-Domains

Mark S. Johnson and Danny Tuckwell

In humans, I domains are ~200 residue long sequences that are “inserted” into the N-terminal domain of all 8 integrin a subunits and 9 of the 18 integrin

Chapter category: Adhesion Molecules

Function of a2b1 Integrin

Additional chapters from this book:

SIGN IN