Chapter category: Adhesion Molecules
Collagen-Binding Integrins and Disease
I Domains in Integrins
Edited by: Donald GullbergISBN: 0-306-47836-6
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Chapter authors:
Beate Eckes, Bernhard Nieswandt and Thomas Krieg
Among the b1 family of integrin receptors there are 4 receptors that mediate bind ing to different collagens. These are a1a, a2b, a10b1 and a11b1 (Fig. 1). Their specific structural and functional properties are covered in detail in different chapters of this book. Since collagens represent the most abundant constituent of the extracellular matrix (ECM) in nearly the entire vertebrate body, correct recognition of this environment and signal transduction elicited by integrin-collagen interaction appears vital for proper function. Common to all four receptors and prerequisite for collagen binding is the “inserted” or I-domain (also called von Willebrand A-domain), a structural motif of 180-200 amino acids in length present in the N-terminal half of the a-ectodomains (for recent reviews, see1,2).
Obviously, diseases associated with collagen-binding integrins could result from mutations in either receptor or ligand that affect binding, activation and/or signaling. Moreover, the tissue distribution of each individual receptor will determine to a large extent the potential damage of its dysfunction, while expression of two or more of these receptors on a given cell type will possibly alleviate the damage arising from one particular malfunctioning receptor. To understand the specific functions of the individual collagen receptors, and which functions can also be fulfilled by the others, knockout mouse models have been generated3-5 or will be available in the future for functional studies.
Additional chapters from this book:
Structure and Activation of b2 - Integrins
Carl G. Gahmberg and Susanna Fagerholm
Cellular adhesion is essential for several leukocyte functions. A number of adhesion molecules are involved in various adhesive events, but perhaps the most important are the leukocyte specifi...
Integrins in Immune and Inflammatory Disease
Antonin R. de Fougerolles
The adhesive interactions of cells with other cells and with extracellular matrix have a central role in regulating immune and inflammatory responses. Integrins are capable of acting at differ...
Collagen-Binding Integrins and Disease
Beate Eckes, Bernhard Nieswandt and Thomas Krieg
Among the b1 family of integrin receptors there are 4 receptors that mediate bind ing to different collagens. These are a1
Cellular Signaling by Collagen-Binding Integrins
Jyrki Heino
Collagens are structural proteins of extracellular matrix that typically have triple helical domains of variable length.1 Collagens form, for example, the large fibers of connec tive tissues a...
Integrin Recognition Motifs in Collagens
Richard W. Farndale
The vertebrate integrins are a family of twenty four heterodimeric transmembrane sig nalling and adhesion molecules, found in very many cells types where their expression and affinity is caref...
Structural Aspects of Integrins
Robert C. Liddington
Structural studies on integrins have recently made great strides. In the past three years, crystal structures of the complete extracellular fragment of one integrin, a
Integrin aEb7: Molecular Features and Functional Significance in the Immune System
Peter J. Kilshaw and Jonathan M.G. Higgins
Abstract Alpha E beta 7 is an a-I domain-containing integrin that is expressed mainly on T cells, dendritic cells and mast cells in mucosal tissues. Expression depen...
Structure and Function of a11b1
Donald Gullberg, Svetlana N. Popova and Carl-Fredrik Tiger
The a11 integrin chain constitutes the latest addition to the integrin family. a11b1 was originally identified ...
Structure Distribution and Function of a10b1
Evy Lundgren-Åkerlund and Max Schneller
Introduction The integrin a10b1 was originally identified as a collagen type II binding integrin on chondrocytes.1 The bovine integrin sub...
Function of a2b1 Integrin
Mary M. Zutter and Samuel A. Santoro
The a2b1 integrin serves as an extracellular matrix receptor for collagen and /or laminin, as well as several other nonmatrix ligands.1-3 ...
Integrin a1b1
Humphrey Gardner
Introduction The integrin a1 subunit was first discovered by Hemler et al as the a component of the Very Late Antigen I (VLA1) expresse...
Evolution of Integrin I-Domains
Mark S. Johnson and Danny Tuckwell
In humans, I domains are ~200 residue long sequences that are “inserted” into the N-terminal domain of all 8 integrin a subunits and 9 of the 18 integrin
