Chapter category: Cell Cycle
Regulation of Signaling and the Cell Cycle by Cell Interactions with the Extracellular Matrix
G1 Phase Progression
Edited by: Johannes BoonstraISBN: 0-306-47831-5
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Chapter authors:
R.L. Juliano
Adhesive interactions with the extracellular matrix, mediated primarily by integrins and transmembrane proteoglycans, play a key role in regulating the G1 phase of the cell cycle. A primary aspect of this is adhesion regulation of important signaling pathways, particularly the Erk/MAP Kinase cascade. The regulation exerted by matrix is quite complex; and takes place at several different levels of the signaling pathway. While some aspects of adhesion regulation of signaling seem to function ubiquitously, encompassing many different cell types and different matrix molecules, other aspects are influenced by the precise composition of the matrix and the transmembrane proteins interacting with matrix. Since there are over twenty distinct mammalian integrins, it seems likely that we are just beginning to understand the more specific aspects of integrin and matrix regulation of mitogenic signaling.
Additional chapters from this book:
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Progression from G0 through G1 and into S on Two Waves of Growth Factor-Driven Signaling
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A widely used model system to investigate cell proliferation is stimulation of serum-arrested cells with growth factors. Recent data suggest that there are two waves of growth factor-dependent signa...
Impact of Nutrients on the Cell Cycle of Saccharomyces cerevisiae
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The Role of Reactive Oxygen Species in G1 Phase Progression
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Role of Cyclins and Cyclin-Dependent Kinases in G1 Phase Progression
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Cyclin and the cyclin dependent kinases (CDKs) are the principle regulators of cell cycle progression through activation of cell cycle checkpoints. These are the core of the complex that compose...
Role of RB/E2F in G1 Phase Progression
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The progression from G1 to S phase requires the de novo expression of genes that en code proteins and enzymes involved in DNA replication. Regulation of these S-phase genes is, therefore, an impo...
Regulation of Signaling and the Cell Cycle by Cell Interactions with the Extracellular Matrix
R.L. Juliano
Adhesive interactions with the extracellular matrix, mediated primarily by integrins and transmembrane proteoglycans, play a key role in regulating the G1 phase of the cell cycle. A primary aspe...
G1 Phase Control and Cell Differentiation
María J. Muñoz-Alonso and Javier León
Cell differentiation is usually accompanied by irreversible cell cycle exit. The G1 regula tory molecules have been shown to be exquisitely regulated during the differentiation process and in man...
Cell Cycle Regulation During G1 Phase in Yeast: Decisions, Decisions, Decisions
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Coordination of cell cycle events is essential for the faithful duplication of cellular com- ponents during proliferation as well as for the adaptability of cells and organisms to varying interna...
Roles of Cyclin Kinase Inhibitors in G1 Phase Progression
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Cell cycle progression is tightly controlled by cyclin/Cyclin dependent kinase (CDK) complexes. Two families of cyclin kinase inhibitors have been identified based on their structures and affini...
Restriction Points in the G1 Phase of the Mammalian Cell Cycle
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Progression through the cell cycle of mammalian cells is dependent upon external factors such as growth- and extracellular matrix factors. On the other hand, cell cycle progres sion can be inhibi...
Progression from G0 through G1 and into S on Two Waves of Growth Factor-Driven Signaling
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A widely used model system to investigate cell proliferation is stimulation of serum-arrested cells with growth factors. Recent data suggest that there are two waves of growth factor-dependent...
Regulation of G1 Phase of Yeast Cells by Stress
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Different environmental stresses, among them heat, hyperosmotic and oxidative ones, cause yeast cells to arrest at G1. The duration of the arrest is proportional to the intensity of the stress...
