Chapter category: Stem Cells
Extra and Intraembryonic HSC Commitment in the Avian Model
Hematopoietic Stem Cell Development
Edited by: Isabelle Godin and Ana CumanoISBN: 0-306-47872-2
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Chapter authors:
T. Jaffredo, K. Bollerot, K. Minko, R. Gautier, S. Romero and C. Drevon
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Additional chapters from this book:
Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo
Julien Yuan Bertrand, Alexandra Manaia, Jeanne Van Celst, Ana Cumano and Isabelle Godin
The hematopoietic system comprises a large array of differentiated cells (lymphocytes, myeloid cells, erythrocytes, etc…) with a limited half-life. The hematopoietic com- partment thus depends ...
Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem Cell Differentiation
Jussi Liippo* and Olli Lassila
Hematopoiesis starts in the yolk sac blood islands and in a region of dorsal aorta in the early embryo. Interest in the emergence of the hematopoietic stem cells in the embryo proper has increased i...
Long-Term Reconstituting Hematopoietic Stem Cell Capacity of the Embryo
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Hematopoiesis is the dynamic process whereby all formed elements of the blood arise from multipotent precursor cells. In the adult mouse, hematopoiesis occurs primarily within the medullary cavity o...
Yolk Sac Development in Mice
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A functional cardiovascular system is essential for survival and growth of the mammalian embryo, so the hematopoietic, vascular, and cardiac organ systems are the first to emerge in early post-impla...
Intraembryonic Development of Hematopoietic Stem Cells During Human Ontogeny Expression Analysis
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The adult hematopoietic system is composed of a number of different cell types, including erythrocytes and cells of the myeloid and lymphoid lineages. It is generally believed that all these cell ty...
Endothelial and Hematopoietic Cells in the Intra-Embryonic Compartment
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The development of endothelial cells and hematopoietic cells is closely related at embryonic stages, and both cells share a common precursor, the hemangioblast. Differentiation into hematopoietic an...
The Endothelium—The Cradle of Definitive Hematopoiesis?
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It has been more than 80 years since a lineage relationship between hematopoietic and endothelial cells in the form of a bipotential precursor – the hemangioblast – was first proposed. Evidence ...
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Drosophila hematopoiesis includes two distinct phases. The first phase occurs during the second half of embryonic development, whereas the second hematopoietic phase occurs during the larval sta...
Gene and Cell Therapy Involving Hematopoietic Stem Cell
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Hematopoietic Stem Cells (HSC) possess two characteristics, long term self-renewal capacity and pluripotentiality, that render them able to develop into the different blood cell lineages. HSC tr...
Extra and Intraembryonic HSC Commitment in the Avian Model
T. Jaffredo, K. Bollerot, K. Minko, R. Gautier, S. Romero and C. Drevon
Hematopoietic Stem Cells (HSC) are at the basis of the hematopoietic system con- struction. In adult higher Vertebrates, HSC, defined by their multipotentiality and self-renewal capacity, settle ...
Genetic Dissection of Hematopoiesis Using the Zebrafish
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Hematopoiesis during embryogenesis and adult life has been extensively studied in several vertebrate models. The zebrafish (Danio rerio) has recently provided a power- ful genetic system to furth...
Ventral and Dorsal Contributions to Hematopoiesis in Xenopus
Aldo Ciau-Uitz, Maggie Walmsley and Roger Patient
The view that all blood derives from ventral mesoderm has been challenged in recent years. In the Xenopus embryo, it is now clear that the embryonic blood compartment, the ventral blood island ...
