Chapter category: Vaccines
Anti-Tumor Immunotherapy with Synthetic Peptides Representing Tumor-Associated T-Cell Epitopes: Implications for Peptide-Based Vaccination of Cervical Cancer
Vaccines for Human Papilloviruses Infection and Anogenital Disease
Edited by: Robert W. TindleISBN: 1-57059-589-5
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Chapter authors:
Maaike E. Ressing, René E.M. Toes, Stephen P. Schoenberger, Remco M.P. Brandt, Joan H. de Jong, W. Martin Kast, Rienk Offringa and Cornelis J.M. Melief
Alternative approaches for the prevention or treatment of cancer are now emerging. The goal of new treatment modalities is to combine effective anti-tumor activity with a reduction of the side effects to healthy tissues, still constituting a severe complication of conventional cancer therapy (i.e., of surgery, radiotherapy, and chemotherapy). Observations that susceptibility to several cancer types is increased in immunocompromized individuals has led to the assumption that immune responses are able to interfere with tumor development.1 Immunotherapy aims at increasing the power, and redirecting the specificity, of the patients’ immune system to attack the malignant cells without the often severe side effects associated with conventional cancer treatment.
Additional chapters from this book:
Live Recombinant Vaccine Vectors for HPV Antigens Associated with Infection and Malignancy
Abba C. Zubair, Yvonne Paterson and Elwyn Y. Loh
Classical vaccines for polio, small pox, and influenza use attenuated viruses to induce immunity in diseases where first time exposure normally elicits protective immunity against a second infection...
Experimental Vaccine Strategies for Cancer Immunotherapy
Stefanie L. Stevenson and T.C. Wu
The ideal cancer therapy for advanced cervical cancers should have the potency to eradicate systemic tumor in multiple sites in the body, as well as the specificity to discriminate between neoplasti...
DNA Vaccines for Papillomavirus Infections
Sancy A. Leachman and Janet L. Brandsma
The major advances in approaches in vaccinology can be subdivided into three “waves”, each resulting from breakthrough technologies. The initial wave employed newly developed cell culture methods to...
Safety and Immunogenicity of HPV16 E7/Algammulin
Ian H. Frazer, Robert W. Tindle, Germain J.P. Fernando, Karen Malcolm, Karen Herd, Sue McFadyn, Peter D. Cooper and Bruce Ward
T E6 and E7, are together sufficient to immortalize human keratinocytes in vitro,1,2 and the open reading frames encoding these viral proteins are preserved in HPV-associated cervical cancers.3,4 Hu...
Recombinant Vaccinia Virus
Stephen Man, E.M.L. Evans, M. Nimako and L.K. Borysiewicz
Cervical cancer is the second most common female malignancy worldwide and remains a clinical problem despite improvements in early detection and therapy. Cervical cancer (and preinvasive CIN3) is st...
Anti-Tumor Immunotherapy with Synthetic Peptides Representing Tumor-Associated T-Cell Epitopes: Implications for Peptide-Based Vaccination of Cervical Cancer
Maaike E. Ressing, René E.M. Toes, Stephen P. Schoenberger, Remco M.P. Brandt, Joan H. de Jong, W. Martin Kast, Rienk Offringa and Cornelis J.M. Melief
Alternative approaches for the prevention or treatment of cancer are now emerging. The goal of new treatment modalities is to combine effective anti-tumor activity with a reduction of the side effec...
Vaccine for Genital Warts
John St. Clair Roberts, Terry O’Neill, Charles Lacey, David Rowen, Jane Sterling, Eric Monteiro, Louise Clark and Stephen Thompson
G papillomavirus (HPV), principally HPV types 6 and 11.1 They are one of the most common clinically recognized sexually transmitted diseases worldwide, occurring at incidence rates of 1.5-2.5% per y...
HPV Vaccines for Protection Against Infection
Kathrin U. Jansen
The purpose of this chapter is to describe the rationale and scientific evidence for the development of prophylactic human papillomavirus (HPV) vaccines based on the use of recombinant HPV virus-lik...
Immunobiology of HPV Infection
Graham R. Leggatt and Ian H. Frazer
T of epithelial cells. An understanding of the viral life cycle, models of infection and the host immune response is an essential first step in the development of therapeutic or prophylactic vaccine...
Immunomodulation of HPV Infection and Disease: An Overview
Robert W. Tindle
About 50 of the approximately 100 (the number continues to grow) genotypes of human papillomaviruses (HPV) infect the mucous epithelium of the genital tract. HPV genotypes 6, 11, 43 and 44, in parti...
