Chapter category: Autoimmunity
Cytokines and Chemokines in Human Autoimmune Skin Disorders
Cytokines and Chemokines in Autoimmune Disease
Edited by: Pere SantamariaISBN: 0-306-47693-2
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Chapter authors:
Dorothée Nashan and Thomas Schwarz
Autoimmune skin diseases comprise two major groups of disorders, connective tissue diseases and bullous diseases. Connective tissue diseases represent a group of autoimmune disorders with overlapping clinical features including lupus erythematodes and its subtypes, systemic sclerosis, dermatomyositis, Sjögren´s syndrome, and mixed connective disease. Acquired immunobullous diseases include pemphigus vulgaris and its associated entities, bullous pemphigoid, and dermatitis herpetiformis. In the following clinical features, immuno-serological profile, and immunogenetic background for each disease will be briefly discussed to focus on the pathomechanisms with special emphasis on cytokines and chemokines. Improving knowledge concerning the precise immunopathogenesis will provide the ability to target specific mediators and effector cells involved in the disease. Hence therapeutic perspectives will be discussed at the end of the Chapter.
Additional chapters from this book:
The Role of Cytokines as Effectors of Tissue Destruction in Autoimmunity
Thomas W.H. Kay, Rima Darwiche, Windy Irawaty, Mark M.W. Chong, Helen E. Thomas
Target cell damage in autoimmune disease is likely to be mediated by multiple effector pathways only some of which are cytokines. Recent progress in cell death research has dramatically cha...
Cytokines, Lymphocyte Homeostasis and Self Tolerance
Yiguang Chen and Youhai Chen
Cytokines play pivotal roles in maintaining lymphocyte homeostasis and self tolerance. Cytokines are required for activating and inactivating as well as deleting cells of the immune system ...
Cytokines and Chemokines in Autoimmune Disease: An Overview
Pere Santamaria
Autoimmune diseases result from complex interactions among different immune cell types, including both T and B lymphocytes and professional antigen–presenting cells, such as macrophage...
Cytokines and Chemokines n the Pathogenesis and Treatment of Inflammatory Bowel Disease
Deborah O'Neil and Lothar Steidler
Chronic inflammatory bowel disease is the term applied to a spectrum of gastrointestinal immunopathologies of which Crohn's disease and ulcerative colitis are the most common. Ulcerative colit...
Involvement of Cytokines in the Pathogenesis of Systemic Lupus Erythematosus
B.R. Lauwerys and F.A. Houssiau
Systemic lupus erythematosus (SLE) is characterized by overt polyclonal B-cell activation and autoantibody (Ab) production. By contrast, cellular immune responses against allo- or recall antig...
Cytokines and Chemokines in Human Autoimmune Skin Disorders
Dorothée Nashan and Thomas Schwarz
Autoimmune skin diseases comprise two major groups of disorders, connective tissue diseases and bullous diseases. Connective tissue diseases represent a group of autoimmune disorders with over...
Cytokines in the Treatment and Prevention of Autoimmune Responses
Xin Xiao Zheng, Wlodzmierz Maslinski, Sylvie Ferrari-Lacraz and Terry B. Strom
Cytokines are important protein mediators of immunity, inflammation, cell prolifer- ation, differentiation, and fibrosis.1 These are the major biological processes un-derlying autoi...
Cytokines and Chemokines in Virus-Induced Autoimmunity
U Christen and M von Herrath
Virus infections usually elicit a massive inflammatory reaction characterized by release of chemokines and cytokines that attract and activate cells of the host's immune system with the goal t...
Cytokines in the Pathogenesis of Rheumatoid Arthritis and Collagen-Induced Arthritis
Erik Lubberts and Wim B. van den Berg
The cytokine network in rheumatoid arthritis (RA) is a complex field, with a lot of cytokines showing pleiotropic actions and many different targets. To keep it simple, the network...
Immunoregulation by Cytokines in Autoimmune Diabetes
Alex Rabinovitch
In the previous Chapter, Meagher and colleagues discuss the role of a number of cytokines and chemokines in the pathogenesis of murine type 1 (insulin dependent) diabetes mellitus. Here I provide ...
Cytokines and Chemokines in the Pathogenesis of Murine Type 1
C. Meagher, S. Sharif, S. Hussain, M. J. Cameron, G. A. Arreaza and T. L. Delovitch
The immune system can be considered as an intricate set of cell-cell interactions initiated by exposure to antigen and regulated by multiple positive and negative signals derived from lymphocy...
Chemokines in Experimental Autoimmune Ecephalomyelitis and Multiple Sclerosis
Alicia Babcock and Trevor Owens
Chemokines are small molecules that direct leukocyte traffic and play a role in cellular activation. Multiple sclerosis (MS) and experimental autoimmune enc...
Cytokines in the Pathogenesis and Therapy
David O. Willenborg and Maria A. Staykova
In the inflammatory diseases autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) the occurrence, severity, course and resolution of disease are dependent on a complex interaction of...
The Role of Cytokines as Effectors of Tissue Destruction in Autoimmunity
T Kay, R Darwiche, Wi Irawaty et al
Target cell damage in autoimmune disease is likely to be mediated by multiple effector pathways only some of which are cytokines. Recent progress in cell death research has dramatically change...
Cytokine and Cytokine Receptor Genes in the Susceptibility
Hélène Coppin, Marie-Paule Roth and Roland S. Liblau
It is beyond the scope of this Chapter to review exhaustively the research on all autoimmune diseases. We will instead focus on three highly-prevalent chronic inflammat...
Cytokines, Chemokines and their Receptors
Mark J. Cameron and David J. Kelvin
The immune system is skilled in communication and designed to respond quickly, specifically and globally to protect an organism against foreign invaders and disease. The cytokine superfamily o...
