Chapter category: Neuropharmacology
Endocannabinoids and Related Fatty Acid Derivatives in Pain Modulation: Behavioral, Neurophysiological and Neuroanatomical Perspectives on Cannabinoid Antinociception
Cannabinoids
Edited by: Vincenzo Di MarzoISBN: 0-306-48228-2
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Chapter authors:
Andrea G. Hohmann and J.Michael Walker
Cannabinoids are antinociceptive in animal models of acute and persistent nociception. This review examines the biology of endocannabinoids and behavioral, neurophysi ological and neuroanatomical evidence supporting a role for cannabinoids in modulation of nociceptive transmission. The development of subtype selective competitive antagonists and high affinity agonists provides the pharmacological tools required to study cannabinoid antinociceptive mechanisms. Pharmacological approaches, in conjunction with the quantification of endocannabinoids through the use of liquid and gas chromatography mass spectrometry has provided insight into the functional roles of cannabinoids in antinociceptive mechanisms. Effects of cannabinoids in animal models of acute and persistent (somatic inflammatory, visceral inflammatory, neuropathic) nociception are reviewed. Neuroanatomical studies employing receptor binding and quantitative autoradiography, immunocytochemistry and in situ hybridization are reviewed to examine the distribution of cannabinoid receptors and provide a neuroanatomical framework with which to understand the roles of endogenous cannabinoids in sensory processing.
Additional chapters from this book:
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