Chapter category: Immunology
The Use of Gene-Targeted Mice in Contact Hypersensitivity Research
Immune Mechanisms of Allergic Contact Dermatitis
Edited by: Andrea CavaniISBN: 1-58706-209-7
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Chapter authors:
Binghe Wang, Brandon G Howell, Adam J Mamelak and Daniel N Sauder
Contact hypersensitivity (CHS), clinically presenting as allergic contact dermatitis, is a T cell-mediated cutaneous immune inflammatory response to reactive haptens. Al though CHS is generally thought of as a Langerhans cell-dependent, Th1 type immune reaction, much is unknown about the complicated molecular mechanisms underlying CHS. With the advent of gene-targeting technology, a variety of gene knockout mouse models have been used in CHS research. Such studies have significantly contributed to our understanding of the molecular mechanisms comprising the CHS response. This review article summarizes about 70 different gene knockouts used to date in the field of CHS and discusses the contributions these studies have made toward understanding the molecular requirements for CHS initiation.
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Contact hypersensitivity (CHS), clinically presenting as allergic contact dermatitis, is a T cell-mediated cutaneous immune inflammatory response to reactive haptens. Al though CHS is generally thou...
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