IL-10 and Systemic Lupus Erythematosus

Simone Mocellin

Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characterized by B cell hyperactivity leading to excessive auto-antibody production.1,2 SLE patients have high levels of circul...

IL-10, Genetic Polymorphism and Its Relevance to Age-related Diseases

Domenico Lio and Calogero Caruso

The process of life for the individual is the struggle to preserve its integrity. However, the preservation of the integrity of the organism comes with a price, systemic inflammation. Accordingly, a...

The Role of IL-10 in Autoimmune Pathology

Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu and Robert P. Kimberly

The association of high levels of IL-10 with autoimmune diseases suggests that this cytokine plays an important role in the disease pathogenesis. Family studies of first-degree relatives and analysi...

IL-10 Gene Polymorphisms in Transplantation

Andrey Morgun, Natalia Shulzhenko and Maria Gerbase-DeLima

Transplantation is currently the treatment of choice for end-stage insufficiency of various organs and severe hematologic disorders. Cytokine gene polymorphisms have been extensively explored in tra...

Interleukin-10 Gene Polymorphisms and Cancer

W. Martin Howell

Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and anti-angiogenic functions. In consequence, IL-10 can have both tumor-promoting and tumor-inhibiting properties. R...

IL-10: Role in Infectious Diseases

M. Kryworuchko, W. David Creery and Ashok Kumar

Interleukin-10 (IL-10) is a pleiotropic cytokine produced by monocytes/macrophages, B cells, and various subsets of T cells including T helper type 2 (Th2), Th0 cells, and regula tory T (Tr) cells a...

A Chapter on “IL-10 Effects on Innate Immunity”

Shin-ichiro Fujii and Michael T. Lotze

IL-10 is a dichotomous functional cytokine. It has characteristics of being both an immu nosuppressive and immunostimulatory cytokine. In the setting of many infectious diseases including some viral...

Interleukin-10 and Psoriasis

Interleukin (IL)-10 is an important immunoregulatory cytokine. One of its main biological function seems to be the limitation and termination of inflammatory responses. Remarkably, a relative deficien...

Role of IL-10 in Autoimmune Pathology

The mechanisms involved in initiating and maintaining the inflammatory response associated with autoimmune diseases is yet to be defined. Nevertheless, cytokines with pro-inflammatory or anti-inflamma...

Role of Interleukin-10 in Transplantation

Thomas Ritter and Hans-Dieter Volk

Organ transplantation has been developed as ultimative option in patients with end-stage organ diseases. New immunosuppressive regimens and improved perioperative management did improve the short-te...

Interleukin-10 in Allergic Disease

Peter J. Barnes

IL-10 plays a key regulatory role in allergic diseases. It is produced by many of the inflam matory cells involved in allergic inflammation, including macrophages, regulatory T lym phocytes, dendrit...

Structure and Function of IL-10 and the IL-10 Receptor

Alexander Zdanov

Interleukin-10 (IL-10) is a cytokine the primary function of which appears to be to limit and control inflammatory responses. It signals through interactions with two receptor chains: high affinity ...

IL-10: The Role in Crohn’s Disease

James Lindsay

The gastrointestinal tract serves as a barrier between the host and the vast array of foreign antigen that is contained within its lumen. The mucosal immune system must balance two opposing function...

Role of IL-10 in Cancer

Monica C. Panelli and Francesco M. Marincola

The pleiotropic effects of interleukin 10 (IL-10) are at the basis of the controversy about its role in the control of innate and adaptive immune responses where it could play in different experimen...

Role of IL-10 in Autoimmune Pathology

Almeras Lionel and Prin Lionel

The mechanisms involved in initiating and maintaining the inflammatory response associated with autoimmune diseases is yet to be defined. Nevertheless, cytokines with pro-inflammatory or anti-inflam...

Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis

Joachim Sieper and Martin Rudwaleit

Reactive arthritis (ReA) and ankylosing spondylitis (AS) are part of the so called spondyloarthropathies which also include arthritis/spondylitis with inflammatory bowel (IBD) disease and arthritis/...

Interleukin-10 and Adaptive Immune Response

Simone Mocellin, Carlo Riccardo Rossi and Pierluigi Pilati

IL-10 is a pleiotropic cytokine that is produced by a variety of hematopoietic cells (e.g., CD4+ T cells, NK cells, macrophages, dendritic cells)1-4 and regulates the function of several adaptive im...

Experimental Models for the Analysis of IL-10 Function

Carl G. Feng, Julio Aliberti, Karl F. Hoffmann, Dragana Jankovic, Marika C. Kullberg, Alan Sher and Thomas A. Wynn

This review focuses on the regulatory functions of IL-10 in the response to parasitic and bacterial infection revealed through knockout, cytokine/receptor blocking, and transgenic mouse studies....

Interleukin-10: Genetic Polymorphisms and Relevance to Autoimmune Pathology

Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu and Robert P. Kimberly

The association of high levels of IL-10 with autoimmune diseases suggests that this cytokine plays an important role in the disease pathogenesis. Family studies of first-degree rela tives and ana...