Chapter category: Cytokines/Growth Factors
Interleukin-10 in Allergic Disease
Interleukin-10
Edited by: Francesco M. MarincolaISBN: 1-58706-285-2
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Chapter authors:
Peter J. Barnes
IL-10 plays a key regulatory role in allergic diseases. It is produced by many of the inflam matory cells involved in allergic inflammation, including macrophages, regulatory T lym phocytes, dendritic cells, mast cells and eosinophils. IL-10 suppresses allergic inflammation by inhibiting the expression of inflammatory cytokines, Th2 cell-derived cytokines, chemokines and inflammatory mediator enzymes. In addition, it suppresses antigen presentation and increases the production of endogenous anti-inflammatory molecules. There is increasing evidence for defective production of IL-10 in allergic diseases, including asthma and rhinitis and this is associated with disease severity. This may lead to amplification of the inflammatory response in allergic diseases. It may be determined by polymorphisms of the IL-10 promoter linked to low endogenous IL-10 production. IL-10 itself may be a therapeutic approach to allergic disease, but because of side effects stimulation of endogenous IL-10 production may be a more useful approach. Corticosteroids restore the impaired IL-10 secretion in asthma and specific immunotherapy increases IL-10 production by regulatory T cells. Novel therapies in the future might include drugs that selectively activate IL-10 signal transduction pathways.
Additional chapters from this book:
IL-10 and Systemic Lupus Erythematosus
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IL-10, Genetic Polymorphism and Its Relevance to Age-related Diseases
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Interleukin-10 Gene Polymorphisms and Cancer
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IL-10: Role in Infectious Diseases
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A Chapter on “IL-10 Effects on Innate Immunity”
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IL-10 is a dichotomous functional cytokine. It has characteristics of being both an immu nosuppressive and immunostimulatory cytokine. In the setting of many infectious diseases including some viral...
Role of Interleukin-10 in Transplantation
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Interleukin-10 in Allergic Disease
Peter J. Barnes
IL-10 plays a key regulatory role in allergic diseases. It is produced by many of the inflam matory cells involved in allergic inflammation, including macrophages, regulatory T lym phocytes, dendrit...
Structure and Function of IL-10 and the IL-10 Receptor
Alexander Zdanov
Interleukin-10 (IL-10) is a cytokine the primary function of which appears to be to limit and control inflammatory responses. It signals through interactions with two receptor chains: high affinity ...
IL-10: The Role in Crohn’s Disease
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The gastrointestinal tract serves as a barrier between the host and the vast array of foreign antigen that is contained within its lumen. The mucosal immune system must balance two opposing function...
Role of IL-10 in Cancer
Monica C. Panelli and Francesco M. Marincola
The pleiotropic effects of interleukin 10 (IL-10) are at the basis of the controversy about its role in the control of innate and adaptive immune responses where it could play in different experimen...
Role of IL-10 in Autoimmune Pathology
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The mechanisms involved in initiating and maintaining the inflammatory response associated with autoimmune diseases is yet to be defined. Nevertheless, cytokines with pro-inflammatory or anti-inflam...
Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis
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Interleukin-10: Genetic Polymorphisms and Relevance to Autoimmune Pathology
Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu and Robert P. Kimberly
The association of high levels of IL-10 with autoimmune diseases suggests that this cytokine plays an important role in the disease pathogenesis. Family studies of first-degree rela tives and ana...
