Chapter category: Angiogenesis
Hypoxic Regulation of VEGF
VEGF and Cancer
Edited by: Judith H. HarmeyISBN: 0-306-47988-5
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Chapter authors:
Nina S. Levy, Ilana Goldberg-Cohen and Andrew P. Levy
The induction of VEGF is an important step in the angiogenic response to hypoxia. Molecular studies have determined that VEGF is regulated primarily at the level of the mRNA. Specifically, hypoxia leads to an increase in the transcription of VEGF as well as an increase in the stability of the message. Two major proteins, which mediate these effects, are hypoxia inducible factor, HIF-1, and HuR, respectively. HIF-1 binds to the VEGF promoter and forms a complex that activates transcription of the VEGF gene. Hypoxia stimulates HIF-1 activity by inhibiting the rapid degradation of the HIF-1 ? subunit via the ubiquitin proteosome pathway. The mechanism of HuR stabilization of VEGF mRNA is less well understood but appears to act by displacing RNases that mediate rapid degradation of VEGF mRNA. This review summarizes the work which led to these findings and highlights disease processes that may result from faulty hypoxic regulation of VEGF.
Additional chapters from this book:
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VEGF in Esophageal Cancer
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Breast cancer, as with most solid tumors, needs to develop the angiogenic phenotype for invasiveness, progression and metastasis. Several studies have determined that the degree of peritumoral vascu...
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Angiogenesis is a complex process that occurs in a series of inter-related steps, and involves the release of pro-angiogenic factors. One of the most important angiogenic factors is vascular endothe...
Hypoxic Regulation of VEGF
Nina S. Levy, Ilana Goldberg-Cohen and Andrew P. Levy
The induction of VEGF is an important step in the angiogenic response to hypoxia. Molecular studies have determined that VEGF is regulated primarily at the level of the mRNA. Specifically, hypoxia l...
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The development of a vascular supply is a highly complex process. Work done over the last decade has elucidated the critical role of vascular endothelial growth factor (VEGF) in the regulation of no...
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The study of genes involved in angiogenesis allows clarification of molecular and cellular events related to this phenomenon, as well as identification of new prognostic markers and new targets ...
