Chapter category: Cytokines/Growth Factors
Role of Interleukin-10 in Transplantation
Interleukin-10
Edited by: Francesco M. MarincolaISBN: 1-58706-285-2
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Chapter authors:
Thomas Ritter and Hans-Dieter Volk
Organ transplantation has been developed as ultimative option in patients with end-stage organ diseases. New immunosuppressive regimens and improved perioperative management did improve the short-term results during the last decade, however, insufficient control of chronic rejection and side effects of continuous immunosuppression limit the long-term success of this approach. The immunosuppressive drugs used today suppress both unspecific inflammatory reactions and specific T-cell activation. Unfortunately, these powerful drugs also prevent the activation of the endogenous counterregulatory processes that control the immune response (e.g., regulatory T cells, anti-inflammatory cytokines). Thus, targeting more selective the inflammatory process would be of outstanding interest. IL-10 might be an ideal candidate for this approach as it expresses both direct anti-inflammatory and immunoregulatory properties. Therefore, IL-10 has been administered in various models of cell and organ transplantation using different ways of application which will be discussed in the following chapter.
Additional chapters from this book:
IL-10 and Systemic Lupus Erythematosus
Simone Mocellin
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characterized by B cell hyperactivity leading to excessive auto-antibody production.1,2 SLE patients have high levels of circul...
IL-10, Genetic Polymorphism and Its Relevance to Age-related Diseases
Domenico Lio and Calogero Caruso
The process of life for the individual is the struggle to preserve its integrity. However, the preservation of the integrity of the organism comes with a price, systemic inflammation. Accordingly, a...
The Role of IL-10 in Autoimmune Pathology
Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu and Robert P. Kimberly
The association of high levels of IL-10 with autoimmune diseases suggests that this cytokine plays an important role in the disease pathogenesis. Family studies of first-degree relatives and analysi...
IL-10 Gene Polymorphisms in Transplantation
Andrey Morgun, Natalia Shulzhenko and Maria Gerbase-DeLima
Transplantation is currently the treatment of choice for end-stage insufficiency of various organs and severe hematologic disorders. Cytokine gene polymorphisms have been extensively explored in tra...
Interleukin-10 Gene Polymorphisms and Cancer
W. Martin Howell
Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and anti-angiogenic functions. In consequence, IL-10 can have both tumor-promoting and tumor-inhibiting properties. R...
IL-10: Role in Infectious Diseases
M. Kryworuchko, W. David Creery and Ashok Kumar
Interleukin-10 (IL-10) is a pleiotropic cytokine produced by monocytes/macrophages, B cells, and various subsets of T cells including T helper type 2 (Th2), Th0 cells, and regula tory T (Tr) cells a...
A Chapter on “IL-10 Effects on Innate Immunity”
Shin-ichiro Fujii and Michael T. Lotze
IL-10 is a dichotomous functional cytokine. It has characteristics of being both an immu nosuppressive and immunostimulatory cytokine. In the setting of many infectious diseases including some viral...
Role of Interleukin-10 in Transplantation
Thomas Ritter and Hans-Dieter Volk
Organ transplantation has been developed as ultimative option in patients with end-stage organ diseases. New immunosuppressive regimens and improved perioperative management did improve the short-te...
Interleukin-10 in Allergic Disease
Peter J. Barnes
IL-10 plays a key regulatory role in allergic diseases. It is produced by many of the inflam matory cells involved in allergic inflammation, including macrophages, regulatory T lym phocytes, dendrit...
Structure and Function of IL-10 and the IL-10 Receptor
Alexander Zdanov
Interleukin-10 (IL-10) is a cytokine the primary function of which appears to be to limit and control inflammatory responses. It signals through interactions with two receptor chains: high affinity ...
IL-10: The Role in Crohn’s Disease
James Lindsay
The gastrointestinal tract serves as a barrier between the host and the vast array of foreign antigen that is contained within its lumen. The mucosal immune system must balance two opposing function...
Role of IL-10 in Cancer
Monica C. Panelli and Francesco M. Marincola
The pleiotropic effects of interleukin 10 (IL-10) are at the basis of the controversy about its role in the control of innate and adaptive immune responses where it could play in different experimen...
Role of IL-10 in Autoimmune Pathology
Almeras Lionel and Prin Lionel
The mechanisms involved in initiating and maintaining the inflammatory response associated with autoimmune diseases is yet to be defined. Nevertheless, cytokines with pro-inflammatory or anti-inflam...
Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis
Joachim Sieper and Martin Rudwaleit
Reactive arthritis (ReA) and ankylosing spondylitis (AS) are part of the so called spondyloarthropathies which also include arthritis/spondylitis with inflammatory bowel (IBD) disease and arthritis/...
Interleukin-10 and Adaptive Immune Response
Simone Mocellin, Carlo Riccardo Rossi and Pierluigi Pilati
IL-10 is a pleiotropic cytokine that is produced by a variety of hematopoietic cells (e.g., CD4+ T cells, NK cells, macrophages, dendritic cells)1-4 and regulates the function of several adaptive im...
Experimental Models for the Analysis of IL-10 Function
Carl G. Feng, Julio Aliberti, Karl F. Hoffmann, Dragana Jankovic, Marika C. Kullberg, Alan Sher and Thomas A. Wynn
This review focuses on the regulatory functions of IL-10 in the response to parasitic and bacterial infection revealed through knockout, cytokine/receptor blocking, and transgenic mouse studies....
Interleukin-10: Genetic Polymorphisms and Relevance to Autoimmune Pathology
Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu and Robert P. Kimberly
The association of high levels of IL-10 with autoimmune diseases suggests that this cytokine plays an important role in the disease pathogenesis. Family studies of first-degree rela tives and ana...
