Chapter category: Biotechnology
Imprinted Polymers in Capillary Electrophoresis and Capillary Electrochromatography
Molecular Imprinting of Polymers
Edited by: Sergey Piletsky and Anthony TurnerISBN: 1-58706-219-4
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Chapter authors:
Alessandra Bossi, Pier Giorgio Righetti and Staffan Nilsson
The use of molecularly imprinted polymers (MIPs) as sorbents in capillary electrophoresis (CE) and capillary electrochromatography (CEC) is an attractive way to combine the high selectivity offered by MIPs with the high separation efficiency (106 theoretical plates) and short time of analysis (a few minutes) typical of capillary electrophoresis. An overview of the methods proposed for derivatising the capillary column with MIP-stationary phases is given: from bulk polymerization of MIP directly in the capillary to the most recent micro- and nano-spheres of MIPs for filling the capillary. Examples of applications of imprinting technology applied to capillary electrophoresis are indicated and some future developments are discussed.
Additional chapters from this book:
Business Models for the Commercialisation of MIPs
Peter Leverkus
A high priority for today’s researcher is the need to extract commercial value from a new technology – and MIPs (Molecularly Imprinted Polymers) are no exception to the rule. It is essential to unde...
Molecularly Imprinted Polymers in Drug Screening
Chris Allender
Molecular imprinted polymers (MIPs) are no longer new materials. Three decades have passed since the early Mosbach and Wulff studies1,2 and the technology is rapidly coming of age. However just what...
Solid-Phase Extraction on Molecularly Imprinted Polymers— Requirements, Achievements and Future Work
Lars I. Andersson
Molecular imprint based solid-phase extraction is increasingly being used for selective extraction of biological and environmental samples. Interest in imprinted polymers is derived from the high se...
Chemical Vapor Deposition of Silica Overlayer Using an Organic Molecule As Template on Metal Oxide Surface: Application to Molecular Sieving Sensor and Adsorbent
Naonobu Katada and Miki Niwa
Recent progress is reviewed on the studies carried out to design a reaction field on surfaces consisting purely of metal oxides. Chemical vapor deposition (CVD) of silicon alkoxide, using a molecule...
Molecularly Imprinted Membranes
Mathias Ulbricht
This chapter provides an overview of the emerging and promising field of molecularly imprinted membranes (MIM). The focus is on solid membranes and the separation of molecules, predominately in liqu...
A New Generation of Chemical Sensors Based on MIPs
Sergey Piletsky and Anthony Turner
Molecular imprinting is a generic technology for the introduction of recognition properties into synthetic polymers. Over the last two decades, molecularly imprinted polymers (MIPs) have become a fo...
The Re-Birth of Molecular Imprinting on Silica
Naonobu Katada and Miki Niwa
Molecular imprinting was first attempted between the 1930s – 50s on silica surfaces, but later studies were carried out mainly on organic polymers. However, with advances in technology for the inorg...
MIP Formats for Analytical Applications
Natalia Perez-Moral and Andrew G. Mayes
As MIPS make the gradual transition from the academic research laboratory to application areas, it is essential that the MIP is designed, both chemically and structurally, to optimise its performanc...
MIPs in Biotechnology, Perspective and Reality
David A. Spivak
Over the last five decades, molecularly imprinted polymers (MIPs) have been important as both models and analytical tools for biotechnology. More recently, direct applications as drugs, biosensors, ...
Recognition of Enantiomers Using Molecularly Imprinted Polymers
Borje Sellergren
With the increasing structural complexity of new drugs, the importance of enantiomerically pure compounds is growing.1 Resolution of racemates is often the first step in this process. Conventionally...
MIP Catalysts—From Theory to Practice
Michael J. Whitcombe
The principles of the design of transition state analogues are discussed, illustrated with examples taken from the literature on catalytic antibodies. In the following discussion a number of imprint...
A General Survey of Patents in the Field of Molecularly Imprinted Polymers
Jeffrey B. McIntyre1
This chapter presents a nonexhaustive survey of the types of subject matter for which patent protection has been sought in the field of molecularly imprinted polymers. First, a brief discussion of p...
Imprinted Polymers in Capillary Electrophoresis and Capillary Electrochromatography
Alessandra Bossi, Pier Giorgio Righetti and Staffan Nilsson
The use of molecularly imprinted polymers (MIPs) as sorbents in capillary electrophoresis (CE) and capillary electrochromatography (CEC) is an attractive way to combine the high selectivity offered ...
Bioimprinting
Claudio Baggiani, Cristina Giovannoli
Besides main stream, molecular imprinting based on man-made synthetic polymers or silica-imprinted materials, proteins too can be considered as building blocks to prepare artificial molecular recogn...
Molecularly Imprinted Polymers for Mass Sensitive Sensors – from Cells to Viruses and Enzymes
Franz L. Dickert, Peter A. Lieberzeit, Oliver Hayden
Artificial recognition layers for bioanalytes (cells, bacteria, viruses, proteins etc.) combine biological selectivity with the long-term stability of tailored polymers. They can be produced by surf...
A New Generation of Chemical Sensors Based on MIPs
Sergey Piletsky and Anthony Turner
Molecular imprinting is a generic technology for the introduction of recognition prop erties into synthetic polymers. Over the last two decades, molecularly imprinted polymers (MIPs) have become a f...
Molecularly Imprinted Membranes
Mathias Ulbricht
This chapter provides an overview of the emerging and promising field of molecularly imprinted membranes (MIM). The focus is on solid membranes and the separation of molecules, predominately in liqu...
