Chapter category: Gene Expression
Clusters of Functionally Related Genes in Eukaryotes, Dosage Balance and Evolvability
The Biology of Genetic Dominance
Edited by: Reiner A. VeitiaISBN: 1-58706-288-7
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Chapter authors:
Reiner A. Veitia
There is growing genomic evidence on clustering of functionally related genes in eukaryotes. Recent studies in yeast show a correlation between the expression patterns of adjacent and nonadjacent pairs of genes and that a significant proportion of the former are functionally related. A transcriptome-interactome correlation has provided global evidence that yeast genes with similar expression profiles are more likely to encode interacting proteins. Finally, an analysis of several sequenced eukaryotic genomes found that genes involved in the same pathways were clustered. Stoichiometric imbalances in macromolecular complexes can be a source of dominant phenotypes. Here this “dosage balance hypothesis” is extended with the idea that in many instances the physical association of eukaryotic genes might result from a mechanism selecting “modules” which ensure better coregulation, maintain the right stoichiometry of complexes and facilitate evolution by gene duplication.
Additional chapters from this book:
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Clusters of Functionally Related Genes in Eukaryotes, Dosage Balance and Evolvability
Reiner A. Veitia
There is growing genomic evidence on clustering of functionally related genes in eukaryotes. Recent studies in yeast show a correlation between the expression patterns of adjacent and nonadjacent pa...
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