Chapter category: Neurodegenerative Disease
Role of IL-10 in Autoimmune Pathology
Interleukin-10
Edited by: Francesco M. MarincolaISBN: 1-58706-285-2
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Chapter authors:
The mechanisms involved in initiating and maintaining the inflammatory response associated with autoimmune diseases is yet to be defined. Nevertheless, cytokines with pro-inflammatory or anti-inflammatory activity play a crucial role in the development of auto-aggressive responses, as demonstrated in animal models and human clinical trials. Studies on interleukin (IL)-10—a cytokine that is able to regulate inflammatory and immune responses—can provide insights into the manner in which homeostatic networks modulate disease pathogenesis involving immune dysfonction. Numerous polymorphisms have been detected in the IL-10 promoter, and some of these have been associated with levels of IL-10 production. Here, we review a number of studies that have sought to explore the relationships between IL-10 promoter polymorphisms and the initiation/progression of some autoimmune diseases. As expected, with regard to the pleiotropic role of IL-10 and to the complexity of genetic interactions in autoimmune diseases, the findings are not yet conclusive, but might have indicative value when associated with other markers.
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