Chapter category: Tissue Engineering
Mechanical Modulation of Fracture Healing and Implications for Skeletal Tissue Engineering
Engineered Bone
Edited by: Hervé Petite and Rodolfo QuartoISBN: 1-58706-157-0
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Chapter authors:
A. Goodship
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Additional chapters from this book:
Maxillofacial Bone Regeneration Using Tissue Engineering Concepts
Minoru Ueda
The bone defect in the maxillofacial region generally can be categorized to three types according to the size of defects. The first category is the cavitary bone defect which is less than 3 cms in l...
Gene Therapy for the Enhancement of Fracture Healing
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The ability to introduce exogenous DNA into cells is a powerful tool for researchers in the quest to improve treatment options. Recent years have witnessed increased enthusiasm for gene therapy and ...
Bone Morphogenetic Proteins and Tissue Engineering of Bone
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Tissue engineering is the emerging science of design and manufacture of tissues including bones and joints. The three key ingredients for both tissue engineering and morphogenesis are inductive morp...
Evolution of Skeletal Stem Cell Biology
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More than 30 years ago, Friedenstein demonstrated that in low-density marrow cell cultures, discrete colonies of adherent fibroblast-like cells are formed.20,22 Each colony was generated by prolifer...
Calcium Phosphate Bioceramics: An Alternative to Autograft and Allograft?
Guy Daculsi, Olivier Laboux and Pierre Weiss
Although bone tissue possesses the capacity for regenerative growth, the bone repair process is impaired in many clinical and pathological situations. For example massive bone loss caused by trauma ...
Regulatory Issues: Down to the Bare Bones
Paolo Giannoni and Ranieri Cancedda
In this chapter we propose a brief description of the relevant issues that tissue-engineering researchers must consider when planning new therapeutic approaches, especially in the bone and cartilage...
Repair of Osteochondral Lesions
Ivan Martin, Dirk Schaefer and Beatrice Dozin
Trauma and disease of joints frequently involve structural damage to the articular cartilage surface and the underlying subchondral bone. These pathologies result in severe pain and disability for m...
Bone Healing and Failure
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Facture healing is a complex process resulting from the interaction of cellular elements that are activated and controlled by an array of proinflammatory cytokines and signaling proteins. This proce...
Mechanobiology of Bone
Elisabeth H. Burger, Jenneke Klein-Nulend and Margriet Mullender
Mechanical force is an important regulator of bone formation and resorption. Bone tissue remains adapted to the magnitude and direction of its daily loadings through out life, as a result of continu...
Experimental Animal Models for Tissue-Engineered Bone Regeneration
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Choosing an appropriate experimental model for the study of bone repair necessitates to clearly identify the problem to be solved in order to obtain the right answer to the right question. Animal te...
Clinical Evaluation of BMPs and Bone Marrow Stromal Cells in Orthopedic Surgery
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The development of alternative techniques to treat long bone nonunions or for spinal fusion purposes offers outstanding perspectives for a large number of patients. Among the different approaches av...
Mechanical Modulation of Fracture Healing and Implications for Skeletal Tissue Engineering
A. Goodship
This chapter addresses the factors involved in the functional adaption of intact bone and the relevance of these to mechanical modulation of bone repair. The sensitivity of the repair process to the...
Transcription Factors In Bone: Developmental And Pathological Aspects
X. Yang and Gerard Karsenty
Many transcription factors involved in bone development have been identified through studies of human patients with genetic diseases and of genetically modified mice. Some of them are specific for a...
