Chapter category: Cancer Metastasis
Influence of Cell-Extracellular Matrix Interactions on Keratinocyte Behavior During Repair
Cell Invasion
Edited by: Jyrki Heino and Veli-Matti KähäriISBN: 1-58706-073-6
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Chapter authors:
Brian K. Pilcher, Jonathan C.R. Jones and William C. Parks
The extracellular matrix (ECM), composed of both proteinaceous and nonproteinaceous components, was once thought to merely serve a scaffolding function that provided structural integrity and resiliency to tissues. While this is an important function of the ECM, it is also a key regulator of cell behavior during morphogenic and repair events. Some proteins, such as elastin and many collagen types, are deposited as large, insoluble, protease-resistant fibers. Additionally, several different matrix glycoproteins, such as laminins, fibronectin, thrombospondins, fibrillins, entactin, and many others, form aggregates of various degrees of complexity, providing substrata for cell adhesion and sites for protein-protein interactions. Proteoglycans, in which the mass of carbohydrate exceeds the mass of protein, function in tissue hydration and in a variety of processes related to growth factor/chemokine activity, proteolysis, integrin activation, and more. In addition, extracellular molecules can be organized into specialized structures, such as ligaments, bone, and basement membrane, the matrix upon which epithelia and endothelial cells reside.
Additional chapters from this book:
Keratinocyte Interactions with Fibronectin during Wound Healing
H. Larjava, L. Koivisto and L. Häkkinen
Reepithelialization of wounds is critical for survival. After injury, fibronectinfibrin clot is formed. Keratinocytes become activated and start migrating into the clot....
Influence of Cell-Extracellular Matrix Interactions on Keratinocyte Behavior During Repair
Brian K. Pilcher, Jonathan C.R. Jones and William C. Parks
The extracellular matrix (ECM), composed of both proteinaceous and nonproteinaceous components, was once thought to merely serve a scaffolding function that provided structural integrity and r...
The Plasminogen Activation System in Cell Invasion
M. Patrizia Stoppelli
The plasminogen activator/plasmin system is an enzymatic cascade involved in the control of fibrin degradation, matrix turnover and cell invasion.
Extracellular conversion of the ubiquitou...
Emmprin (CD147), a Tumor Cell Surface Inducer of Matrix Metalloproteinase
Bryan P. Toole
Emmprin is a member of the Ig superfamily that plays an essential role in several normal tissues but is particularly enriched on the surface of malignant tumor cells in vitro and in vivo. T...
Common Mechanistic Features in Cell-Extracellular Matrix Interactions Regulating Neurite Outgrowth and Tumor Cell Invasion
Henri J. Huttunen and Heikki Rauvala
Neurite extension in tissues to establish neuronal connections can be envisioned as a form of invasive migration of growth cones, the distal tips of the neurites that i...
Cancer Invasion-Related Genes
Anja Bosserhoff and Reinhard Buettner
This review provides a brief overview on gene families involved in invasion. Mechanistically, these molecules are involved in deregulation of adhesive interaction of tumor cells with each o...
Matrix Metalloproteinases and Cell Migration in the Development of Cardiovascular Disease
Sarah J. George, Andrew C. Newby and Andrew H. Baker
The matrix metalloproteinase (MMP) family of enzymes has the ability to degrade all components of the extracellular matrix. For this fundamental reason, the MMPs have been implicated in the in...
Integrins in Cancer Cell Invasion
Pekka Koistinen and Jyrki Heino
Integrins are a family of transmembrane glycoprotein receptors that mediate cell-matrix and cell-cell interactions.1,2 Integrins consist of an a and
Matrix Metalloproteinases in Cancer Cell Invasion
Niina Reunanen and VeliMatti Kähäri
Controlled remodeling of extracellular matrix (ECM) is essential for growth, invasion, and metastasis of malignant tumors. Matrix metalloproteinases (MMPs) are a family of secreted zincdepende...
