Chapter category: Signal Transduction
Agonists of Toll-Like Receptor 9: Modulation of Host Immune Responses with Synthetic Oligodeoxynucleotides
Toll and Toll-Like Receptors: An Immunologic Perspective
Edited by: Tina RichISBN: 0-306-48237-1
» Get more information about this book at landesbioscience.com «
Chapter authors:
Ekambar R. Kandimalla and Sudhir Agrawal
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Additional chapters from this book:
Toll Receptors and the Renaissance of Innate Immunity
Elizabeth H. Bassett and Tina Rich
In the last few pages of IMMUNOLOGY-The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab.1 Dismissing the antibody, MHC, the T-cell...
Structures and Motifs Involved in Toll Signalling
Monique Gangloff, Phumzile. L. Ludidi and Nicholas J. Gay
In this article we aim to provide a detailed overview of Toll-like receptor (TLR) structure. Initially we focus on the different ways in which the related vertebrate and invertebrate TLRs recognize ...
Interleukin-1 Receptor/Toll-like Receptor Signaling
Harald Wajant, Peter Scheurich and Frank Henkler
Upon stimulation Interleukin-1 receptor (IL-1R), the related IL-18R as well as the Toll-like receptors (TLRs), trigger signaling pathways that activate the transcription factors, nuclear factor ?B (...
Virus Induced Signaling to Initiate the Interferon Mediated Anti Viral Host Response
Claudia Wietek and Luke A.J. O’Neill
Signaling cascades leading to the activation of an anti-viral host response have been subject to intense investigations over the last decade. Consequently our understanding of the initial switches t...
“Supramolecular” Activation Custers in Innate Immunity
Martha Triantafilou and Kathy Triantafilou
From birth every living organism must contend with an environment replete with infectious pathogens. Mammals and vertebrates have responded to this challenge by developing an intricate system of hos...
The Function of Toll-Like Receptors
Zlatko Dembic
The Toll family of receptors comprises numerous related proteins implicated in the development and defense of plants and animals. Toll was first discovered in Drosophila melanogaster as a gene that ...
Agonists of Toll-Like Receptor 9: Modulation of Host Immune Responses with Synthetic Oligodeoxynucleotides
Ekambar R. Kandimalla and Sudhir Agrawal
Innate immunity is the body’s first line of defense against invading microbes. This component of our immune system relies on highly conserved pattern-recognition receptors (PRRs) to distinguish diff...
Pathogen Avoidance Using Toll Signalling in C. elegans
Nathalie Pujol and Jonathan J. Ewbank
In the fruit fly Drosophila melanogaster, the Toll receptor plays two major roles, one is in early development and the other concerns resistance to infection. In mammals, the mul tiple Toll-Like Rec...
Forward Genetic Analysis of TLR Pathways: A Shared System for the Detection of Endotoxin and Viral Infection
Bruce Beutler, Kasper Hoebe, Philippe Georgel, and Xin Du
The mammalian Toll-like receptors (TLRs) were first recognized as innate immune sen sors when it was discovered that TLR4 is the key component of the mammalian endot oxin (lipopolysaccharide; LPS) r...
The Induction of Dendritic Cell Activation and Maturation by Toll-Like Receptor Signaling
Tsuneyasu Kaisho and Shizuo Akira
The host defense system of higher animals comprises both innate and adaptive immu nity. Dendritic cells (DCs), professional antigen presenting cells, play critical roles in linking these two type...
