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Chapter category: Viruses

Hepatitis Delta Antigen and RNA Polymerase II

This chapter appears in the following book:

Hepatitis Delta Virus

Edited by: Hiroshi Handa and Yuki Yamaguchi
ISBN: 0-387-32230-2
» Get more information about this book at landesbioscience.com «

Chapter authors:
Yuki Yamaguchi and Hiroshi Handa


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Replication and transcription of HDV proceed via RNA-dependent RNA synthesis. These reactions are thought to be catalyzed at least in part by host RNA polymerase II (RNAPII). Hepatitis delta antigen (HDAg), which is critical for these processes, was recently proposed to function as a transcription elongation factor for RNAPII. The involvement of a DNA-dependent RNA polymerase in RNA-dependent RNA synthesis is itself intriguing and poses fundamental questions as to how RNA synthesis initiates, elongates, and terminates on an unusual HDV RNA template. In addition, the presence of a ‘viral’ transcription elongation factor is unprecedented in eukaryotes, whereas a few are known to exist in prokaryotes. Thus, the study of HDV replication and transcription should provide tremendous insight into the basic mechanism underlying RNAPII transcription.

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Additional chapters from this book:

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Hepatitis Delta Antigen and RNA Polymerase II

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Hepatitis Delta Antigen and RNA Polymerase II

Yuki Yamaguchi and Hiroshi Handa

Replication and transcription of HDV proceed via RNA-dependent RNA synthesis. These reactions are thought to be catalyzed at least in part by host RNA polymerase II (RNAPII). Hepatitis delta antigen...

Hepatitis Delta Virus RNA Editing

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The hepatitis delta virus (HDV) is a subviral agent that utilizes the envelope proteins of the hepatitis B virus (HBV) for cell to cell propagation. In infected human hepatocytes, the HDV RNA genome...


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