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Chapter category: Viruses

Diagnosis of Hepatitis D Virus Infection

This chapter appears in the following book:

Hepatitis Delta Virus

Edited by: Hiroshi Handa and Yuki Yamaguchi
ISBN: 0-387-32230-2
» Get more information about this book at landesbioscience.com «

Chapter authors:
Jaw-Ching Wu


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Hepatitis D virus (HDV) is a small defective virus with a single stranded circular RNA of 1.7 kb in size.1-3 Its hepatitis B surface antigen (HBsAg) envelope is provided by the helper hepatitis B virus (HBV) for successful package and transmission of HDV.4,5 The antigenomic strand of HDV encodes a single protein, hepatitis delta antigen (HDAg) of two molecular weight forms. The large form HDAg with a 19-amino acid extension at the C-terminus plays a key role in the package of HDV and suppresses viral replication in a trans-dominant negative manner, while the small form plays an essential role in trans-activating the replication of HDV RNA.

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Additional chapters from this book:

Genotype of Hepatitis Delta Virus

Nobuyuki Enomoto,* Hideki Watanabe, Kazuyoshi Nagayama, Tsuyoshi Yamashiro and Mamoru Watanabe

Hepatitis delta virus (HDV) is a defective virus that requires hepatitis B virus (HBV) surface antigen for virion assembly and infection,1 and contains a negative single stranded circular RNA genome o...

Hepatitis Delta Antigen: Biochemical Properties and Functional Roles in HDV Replication

Michael M.C. Lai

Hepatitis delta antigen (HDAg) was first detected in the nucleus of the hepatocytes of some patients infected with hepatitis B virus (HBV).68 The presence of HDAg was frequently associated with seve...

Hepatitis Delta Antigen and RNA Polymerase II

Yuki Yamaguchi and Hiroshi Handa

Replication and transcription of HDV proceed via RNA-dependent RNA synthesis. These reactions are thought to be catalyzed at least in part by host RNA polymerase II (RNAPII). Hepatitis delta antigen...

Diagnosis of Hepatitis D Virus Infection

Jaw-Ching Wu

Hepatitis D virus (HDV) is a small defective virus with a single stranded circular RNA of 1.7 kb in size.1-3 Its hepatitis B surface antigen (HBsAg) envelope is provided by the helper hepatitis B vi...

Hepatitis Delta Antigen and RNA Polymerase II

Yuki Yamaguchi and Hiroshi Handa

Replication and transcription of HDV proceed via RNA-dependent RNA synthesis. These reactions are thought to be catalyzed at least in part by host RNA polymerase II (RNAPII). Hepatitis delta antigen...

Hepatitis Delta Virus RNA Editing

John L. Casey

The genome of hepatitis delta virus (HDV) is the smallest known to infect man. Encoding just one protein, hepatitis delta antigen (HDAg), HDV relies heavily on host functions and on structural featu...

Structure and Replication of Hepatitis Delta Virus RNA

John M. Taylor

This review focuses on the RNAs of HDV, with emphasis on RNA structure, RNA transcription, and post-transcriptional RNA processing. Included is an evaluation of two current models of HDV RNA replica...

Hepatitis Delta Virus HDV-HBV Interactions

Camille Sureau

The hepatitis delta virus (HDV) is a subviral agent that utilizes the envelope proteins of the hepatitis B virus (HBV) for cell to cell propagation. In infected human hepatocytes, the HDV RNA genome...


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