Chapter category: Cytokines/Growth Factors
IL-10, Genetic Polymorphism and Its Relevance to Age-related Diseases
Interleukin-10
Edited by: Francesco M. MarincolaISBN: 1-58706-285-2
» Get more information about this book at landesbioscience.com «
Chapter authors:
Domenico Lio and Calogero Caruso
The process of life for the individual is the struggle to preserve its integrity. However, the preservation of the integrity of the organism comes with a price, systemic inflammation. Accordingly, ageing is associated with chronic, low-grade inflammatory activity and the major age-related diseases such as Alzheimer’s diseases, Parkinson’s diseases, atherosclerosis and type 2 diabetes, are initiated or worsened by systemic inflammation, thus suggesting the critical importance of unregulated systemic inflammation in the shortening of survival. In the present review, the influence of the anti-inflammatory cytokine interleukin(IL)-10 on these major age-related diseases development is reviewed in the light of the inflammation mechanisms involved in their pathogenesis. The experimental and clinical observations reported suggest that IL-10 may play a central role in protection against major age-related inflammatory diseases. So, typing of IL-10 functionally relevant polymorphisms might allow to evaluate the individual risk for inflammation mediated disease leading to unsuccessful ageing. In fact, it is an emergent evidence that polymorphic alleles of inflammatory cytokines, involved in high cytokine production, are related to unsuccessful ageing and, reciprocally, controlling inflammatory status may allow to better attain successful ageing. So, the major findings reported in recent papers on cytokine polymorphisms and longevity suggest that those individuals who are genetically predisposed to produce low levels of inflammatory cytokines or high levels of anti-inflammatory cytokines (i.e., IL-10) have an increased capacity to reach the extreme limit of human life-span.
Additional chapters from this book:
IL-10 and Systemic Lupus Erythematosus
Simone Mocellin
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characterized by B cell hyperactivity leading to excessive auto-antibody production.1,2 SLE patients have high levels of circul...
IL-10, Genetic Polymorphism and Its Relevance to Age-related Diseases
Domenico Lio and Calogero Caruso
The process of life for the individual is the struggle to preserve its integrity. However, the preservation of the integrity of the organism comes with a price, systemic inflammation. Accordingly, a...
The Role of IL-10 in Autoimmune Pathology
Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu and Robert P. Kimberly
The association of high levels of IL-10 with autoimmune diseases suggests that this cytokine plays an important role in the disease pathogenesis. Family studies of first-degree relatives and analysi...
IL-10 Gene Polymorphisms in Transplantation
Andrey Morgun, Natalia Shulzhenko and Maria Gerbase-DeLima
Transplantation is currently the treatment of choice for end-stage insufficiency of various organs and severe hematologic disorders. Cytokine gene polymorphisms have been extensively explored in tra...
Interleukin-10 Gene Polymorphisms and Cancer
W. Martin Howell
Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and anti-angiogenic functions. In consequence, IL-10 can have both tumor-promoting and tumor-inhibiting properties. R...
IL-10: Role in Infectious Diseases
M. Kryworuchko, W. David Creery and Ashok Kumar
Interleukin-10 (IL-10) is a pleiotropic cytokine produced by monocytes/macrophages, B cells, and various subsets of T cells including T helper type 2 (Th2), Th0 cells, and regula tory T (Tr) cells a...
A Chapter on “IL-10 Effects on Innate Immunity”
Shin-ichiro Fujii and Michael T. Lotze
IL-10 is a dichotomous functional cytokine. It has characteristics of being both an immu nosuppressive and immunostimulatory cytokine. In the setting of many infectious diseases including some viral...
Role of Interleukin-10 in Transplantation
Thomas Ritter and Hans-Dieter Volk
Organ transplantation has been developed as ultimative option in patients with end-stage organ diseases. New immunosuppressive regimens and improved perioperative management did improve the short-te...
Interleukin-10 in Allergic Disease
Peter J. Barnes
IL-10 plays a key regulatory role in allergic diseases. It is produced by many of the inflam matory cells involved in allergic inflammation, including macrophages, regulatory T lym phocytes, dendrit...
Structure and Function of IL-10 and the IL-10 Receptor
Alexander Zdanov
Interleukin-10 (IL-10) is a cytokine the primary function of which appears to be to limit and control inflammatory responses. It signals through interactions with two receptor chains: high affinity ...
IL-10: The Role in Crohn’s Disease
James Lindsay
The gastrointestinal tract serves as a barrier between the host and the vast array of foreign antigen that is contained within its lumen. The mucosal immune system must balance two opposing function...
Role of IL-10 in Cancer
Monica C. Panelli and Francesco M. Marincola
The pleiotropic effects of interleukin 10 (IL-10) are at the basis of the controversy about its role in the control of innate and adaptive immune responses where it could play in different experimen...
Role of IL-10 in Autoimmune Pathology
Almeras Lionel and Prin Lionel
The mechanisms involved in initiating and maintaining the inflammatory response associated with autoimmune diseases is yet to be defined. Nevertheless, cytokines with pro-inflammatory or anti-inflam...
Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis
Joachim Sieper and Martin Rudwaleit
Reactive arthritis (ReA) and ankylosing spondylitis (AS) are part of the so called spondyloarthropathies which also include arthritis/spondylitis with inflammatory bowel (IBD) disease and arthritis/...
Interleukin-10 and Adaptive Immune Response
Simone Mocellin, Carlo Riccardo Rossi and Pierluigi Pilati
IL-10 is a pleiotropic cytokine that is produced by a variety of hematopoietic cells (e.g., CD4+ T cells, NK cells, macrophages, dendritic cells)1-4 and regulates the function of several adaptive im...
Experimental Models for the Analysis of IL-10 Function
Carl G. Feng, Julio Aliberti, Karl F. Hoffmann, Dragana Jankovic, Marika C. Kullberg, Alan Sher and Thomas A. Wynn
This review focuses on the regulatory functions of IL-10 in the response to parasitic and bacterial infection revealed through knockout, cytokine/receptor blocking, and transgenic mouse studies....
Interleukin-10: Genetic Polymorphisms and Relevance to Autoimmune Pathology
Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu and Robert P. Kimberly
The association of high levels of IL-10 with autoimmune diseases suggests that this cytokine plays an important role in the disease pathogenesis. Family studies of first-degree rela tives and ana...
